Chemical Name: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Biological ActivitySmoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Sinha et al.
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Wu et al.
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
Wu et al.
Citations for Purmorphamine
The citations listed below are publications that use Tocris products. Selected citations for Purmorphamine include:
2 Citations: Showing 1 - 2
Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
Authors: Sommer Et al.
Cell Stem Cell. 2018;23:123
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Authors: Yuan Et al.
J Immunol 2016;7:11024
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