Catalog Number: 4551
Chemical Name: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Biological Activity
Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
Technical Data
  • M.Wt:
    520.62
  • Formula:
    C31H32N6O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    483367-10-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
    Sinha et al.
    Nat.Chem.Biol., 2006;2:29
  2. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
    Wu et al.
    J.Am.Chem.Soc., 2002;124:14520
  3. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
    Wu et al.
    Chem.Biol., 2004;11:1229
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Purmorphamine include:

1 Citations: Showing 1 - 1

  1. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
    Authors: Yuan Et al.
    J Immunol 2016;7:11024

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