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Purmorphamine

4551 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4551/10
4551/50
Smoothened Receptor Agonists Small Molecule
1 Image
Description: Smo receptor agonist

Chemical Name: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Technical Data

M.Wt:
520.62
Formula:
C31H32N6O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
483367-10-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Purmorphamine

The citations listed below are publications that use Tocris products. Selected citations for Purmorphamine include:

2 Citations: Showing 1 - 2

  1. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
    Authors: Sommer Et al.
    Cell Stem Cell.  2018;23:123
  2. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
    Authors: Yuan Et al.
    J Immunol  2016;7:11024

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VersaClone cDNA Plasmids

Human Smoothened (NP_005622) VersaClone cDNA

RDC2144

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