Smoothened (Smo) receptor agonist (EC50
~ 1 μ
M). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Sinha et al.
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Wu et al.
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
Wu et al.
The citations listed below are publications that use Tocris products. Selected citations for Purmorphamine include:
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