Chemical Name: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Biological ActivitySmoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
Wu et al.
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Sinha et al.
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Wu et al.
Citations for Purmorphamine
The citations listed below are publications that use Tocris products. Selected citations for Purmorphamine include:
8 Citations: Showing 1 - 8
Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Authors: Lang Et al.
Cell Stem Cell 2019;24:93
FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision.
Authors: Hackland Et al.
Stem Cell Reports 2019;12:920
IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development.
Authors: Yuan Et al.
Cell Death Dis 2019;10:63
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Authors: Sheng Et al.
Nat Commun 2018;9:4047
Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
Authors: Sommer Et al.
Cell Stem Cell. 2018;23:123
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses.
Authors: Rajamani Et al.
Cell Stem Cell 2018;22:698
Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification.
Authors: Kaindl Et al.
Stem Cells Transl Med 2018;
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Authors: Yuan Et al.
J Immunol 2016;7:11024
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Used for the differentiation of human iPSCs into dopaminergic neurons (Kriks et al.,2011).
Purmorphamine was used to differentiate human iPSCs into dopaminergic neurons with above 60% TH positive cells.