Chemical Name: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Biological ActivitySmoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Sinha et al.
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Wu et al.
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
Wu et al.
Citations for Purmorphamine
The citations listed below are publications that use Tocris products. Selected citations for Purmorphamine include:
2 Citations: Showing 1 - 2
Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
Authors: Sommer Et al.
Cell Stem Cell. 2018;23:123
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Authors: Yuan Et al.
J Immunol 2016;7:11024
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Purmorphamine
There are currently no reviews for this product. Be the first to review Purmorphamine and earn rewards!
Have you used Purmorphamine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image