Purmorphamine

Catalog # Availability Size / Price Qty
4551/10
4551/50
Purmorphamine | CAS No. 483367-10-8 | Smoothened Receptor Agonists
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Description: Smo receptor agonist

Chemical Name: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

Purity: ≥98%

Product Details
Citations (8)
Supplemental Products
Reviews (3)

Biological Activity

Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Technical Data

M.Wt:
520.62
Formula:
C31H32N6O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
483367-10-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Usage Information
By Anonymous on 07/04/2020
Application: Species: Mouse

iPSC-derived hypothalamic neuron differentiation activation by Smoothened agonist SAG 1 μM and purmorphamine 1 μM.

PMID: 29681516

For differentiation of DaNs
By Phi Anh Phan on 02/04/2020
Application: Species: Human

Used for the differentiation of human iPSCs into dopaminergic neurons (Kriks et al.,2011).


Great for differentiation of huiPSCs into DaNs!
By Phi Anh Phan on 01/31/2020
Application: Species: Human

Purmorphamine was used to differentiate human iPSCs into dopaminergic neurons with above 60% TH positive cells.


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