Catalog # Availability Size / Price Qty
Purmorphamine | CAS No. 483367-10-8 | Smoothened Receptor Agonists
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Description: Smo receptor agonist

Chemical Name: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

Purity: ≥98%

Product Details
Citations (8)
Supplemental Products
Reviews (3)

Biological Activity

Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Dopaminergic Neurons Derived from hiPSCs using Purmorphamine

 Dopaminergic Neurons Derived from hiPSCs using DAPT

Dopaminergic neurons derived from human induced pluripotent stem cells (hiPSC) using SB 431542 (Cat. No. 1614), CHIR 99021 (Cat. No. 4423), DAPT (Cat. No. 2634) and Purmorphamine. Cells cultured in Neuronal Media supplemented with TGF-3 (Cat. No. 8420-B3, R&D Systems), cAMP, GDNF (Cat. No. 212-GD, R&D Systems), BDNF (Cat. No. 248-BDB, R&D Systems), N21-MAX (Cat. No. AR008, R&D Systems). Differentiation shown at days 55 (left) and 62 (right). Images courtesy of Kevin Flynn, Bio-Techne.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Usage Information
By Anonymous on 07/04/2020
Application: Species: Mouse

iPSC-derived hypothalamic neuron differentiation activation by Smoothened agonist SAG 1 μM and purmorphamine 1 μM.

PMID: 29681516

For differentiation of DaNs
By Phi Anh Phan on 02/04/2020
Application: Species: Human

Used for the differentiation of human iPSCs into dopaminergic neurons (Kriks et al.,2011).

Great for differentiation of huiPSCs into DaNs!
By Phi Anh Phan on 01/31/2020
Application: Species: Human

Purmorphamine was used to differentiate human iPSCs into dopaminergic neurons with above 60% TH positive cells.

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