Catalog Number: 0807
Alternate Names: Gaboxadol
Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Biological Activity
Systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
Technical Data
  • M.Wt:
    176.6
  • Formula:
    C6H8N2O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    85118-33-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Gaboxadol. Lundbeck/Merck
    Huckle
    Curr.Opin.Investig.Drugs, 2004;5:766
  2. 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
    Krogsgaard-Larson
    J.Med.Chem., 1983;26:895
  3. GABAC receptors: relatively simple transmitter-gated ion channels?
    Johnston
    TiPS, 1996;17:319
  4. Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine.
    Krogsgaard-Larson
    Drugs Future., 1984;9:597
Citations:

The citations listed below are publications that use Tocris products. Selected citations for THIP hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurophysiol 2016;36:607
  2. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Authors: Seifi Et al.
    Nature 2014;34:10361
  3. Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.
    Authors: Szemes Et al.
    Mol Brain 2013;6:33
  4. Blindsight depends on the lateral geniculate nucleus.
    Authors: Schmid Et al.
    PLoS One 2010;466:373
  5. Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
    Authors: Krook-Magnuson Et al.
    J Neurosci 2008;100:932

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