THIP hydrochloride

  ( 10 citations )    
Product Datasheet
Catalog Number:0807
Alternate Names:Gaboxadol
Chemical Name:4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
Technical Data
  • M.Wt:
    176.6
  • Formula:
    C6H8N2O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    85118-33-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for THIP hydrochloride include:

10 Citations: Showing 1 - 10
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  1. δ-subunit containing GABAA receptors modulate respiratory networks.
    Authors: Montandon
    Sci Rep  2017;7(1):18105
  2. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurophysiol  2016;36:607
  3. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    Authors: Tong Et al.
    J Neurosci  2015;35:16142
  4. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Authors: Seifi Et al.
    Nature  2014;34:10361
  5. Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.
    Authors: Szemes Et al.
    Mol Brain  2013;6:33
  6. Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
    Authors: Ramaker Et al.
    Neuropharmacology  2012;63:555
  7. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    Authors: Asiedu Et al.
    J Pain  2012;13:546
  8. Potentiating action of propofol at GABAA receptors of retinal bipolar cells.
    Authors: Yue Et al.
    Invest Ophthalmol Vis Sci  2011;52:2497
  9. Blindsight depends on the lateral geniculate nucleus.
    Authors: Schmid Et al.
    PLoS One  2010;466:373
  10. Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
    Authors: Krook-Magnuson Et al.
    J Neurosci  2008;100:932

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