THIP hydrochloride

Tocris Bioscience | Catalog # 0807

GABAA agonist
Tocris Bioscience

Key Product Details

Description

GABAA agonist

Alternative Names

Gaboxadol
View all GABA-A Receptor Agonists »

Product Description

THIP hydrochloride is a systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Product Specifications for THIP hydrochloride

Molecular Weight

176.60

Formula

C6H8N2O2.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride

CAS Number

85118-33-8

PubChem ID

5702253

InChI Key

ZDZDSZQYRBZPNN-UHFFFAOYSA-N

SMILES

Cl.OC1=NOC2=C1CCNC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.66 100
DMSO 17.66 100

Preparing Stock Solutions for THIP hydrochloride

The following data is based on the product molecular weight 176.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.66 mL 28.31 mL 56.63 mL
5 mM 1.13 mL 5.66 mL 11.33 mL
10 mM 0.57 mL 2.83 mL 5.66 mL
50 mM 0.11 mL 0.57 mL 1.13 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

Product Documents for THIP hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for THIP hydrochloride

For research use only

Related Research Areas

GABA Receptors

Citations for THIP hydrochloride

Customer Reviews for THIP hydrochloride (1)

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  • THIP and in vivo chloride signals
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: c57Bl6J
    Verified Customer | Posted 05/23/2019
    injected 8mg/kg I.p. at 1mg/ml in saline
    used with fiber photometry to validate chloride sensor in vivo. response to footshock was measured at baseline and at 20 min intervals post-injection
    THIP hydrochloride 0807

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