Systemically active GABAA
receptor agonist and GABAA
receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
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All Tocris products are intended for laboratory research use only.
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
GABAC receptors: relatively simple transmitter-gated ion channels?
Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine.
Drugs Future., 1984;9:597
The citations listed below are publications that use Tocris products. Selected citations for THIP hydrochloride include:
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