THIP hydrochloride

Catalog # Availability Size / Price Qty
THIP hydrochloride | CAS No. 85118-33-8 | GABA-A Receptor Agonists
1 Image
Description: GABAA agonist
Alternative Names: Gaboxadol

Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride

Purity: ≥98%

Product Details
Citations (13)
Supplemental Products

Biological Activity

THIP hydrochloride is a systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. GABAC receptors: relatively simple transmitter-gated ion channels?
    TiPS, 1996;17:319
  2. 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
    J.Med.Chem., 1983;26:895
  3. Gaboxadol. Lundbeck/Merck
    Curr.Opin.Investig.Drugs, 2004;5:766
  4. Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine.
    Drugs Future., 1984;9:597

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for THIP hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for THIP hydrochloride include:

13 Citations: Showing 1 - 10

  1. Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive.
    Authors: Ki and Lim
    Elife  2019;8
  2. HIV gp120 upregulates tonic inhibition through α5-containing GABAARs.
    Authors: Green and Thayer Et al.
    Neuropharmacology  2019;149:161
  3. δ-subunit containing GABAA receptors modulate respiratory networks.
    Authors: Montandon
    Sci Rep  2017;7(1):18105
  4. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurophysiol  2016;36:607
  5. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    Authors: Tong Et al.
    J Neurosci  2015;35:16142
  6. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Authors: Seifi Et al.
    Nature  2014;34:10361
  7. Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.
    Authors: Szemes Et al.
    Mol Brain  2013;6:33
  8. Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
    Authors: Ramaker Et al.
    Neuropharmacology  2012;63:555
  9. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    Authors: Asiedu Et al.
    J Pain  2012;13:546
  10. Potentiating action of PropF. at GABAA receptors of retinal bipolar cells.
    Authors: Yue Et al.
    Invest Ophthalmol Vis Sci  2011;52:2497


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for THIP hydrochloride

There are currently no reviews for this product. Be the first to review THIP hydrochloride and earn rewards!

Have you used THIP hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.