Catalog Number: 0811
Biological Activity
A potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).
Technical Data
  • M.Wt:
    161.16
  • Formula:
    C6H11NO4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    63088-04-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems.
    Eliasof et al.
    J.Neurochem., 2001;77:550
  2. Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2.
    Mitrovic et al.
    J.Biol.Chem., 1998;273:14698
  3. Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2.
    Vandenberg et al.
    Mol.Pharmacol., 1997;51:809
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