TM N1324 New
Chemical Name: 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one
Biological ActivityPotent and selective GPR39 agonist (IC50 values are 280 and 9 nM in the absence and presence of Zn2+, respectively). Exhibits no significant activity against a panel of 165 other GPCRs. Inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Cell permeable and orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Model-based discovery of synthetic agonists for the Zn2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functions.
Frimurer et al.
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