TM N1324

Catalog # Availability Size / Price Qty
6325/25
6325/5
Orphan 7-TM Receptor Agonists Small Molecule
1 Image
Description: Potent and selective GPR39 agonist; orally bioavailable

Chemical Name: 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective GPR39 agonist (IC50 values are 280 and 9 nM in the absence and presence of Zn2+, respectively). Exhibits no significant activity against a panel of 165 other GPCRs. Inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Cell permeable and orally bioavailable.

Technical Data

M.Wt:
397.79
Formula:
C18H13ClFN7O
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1144477-35-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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