Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate
Biological ActivityTMPH hydrochloride is a potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate.
Papke et al.
Citations for TMPH hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
2 Citations: Showing 1 - 2
Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
Authors: Pinnock Et al.
J Biomed Sci 2015;9:30
Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.
Authors: Peng Et al.
Mol Pharmacol 2013;84:459
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