Catalog Number: 2438
Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate
Biological Activity
Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the University of Florida Research Foundation Inc.
Background References
  1. The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate.
    Papke et al.
    Mol.Pharmacol., 2005;67:1977

The citations listed below are publications that use Tocris products. Selected citations for TMPH hydrochloride include:

Showing Results 1 - 1 of 1

  1. Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
    Authors: Pinnock Et al.
    J Biomed Sci
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