Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α
subunits (i.e. α
4 and β
4 respectively). Displays little inhibition of muscle-type (α
) or α
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The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate.
Papke et al.
The citations listed below are publications that use Tocris products. Selected citations for TMPH hydrochloride include:
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