Torin 1

Tocris Bioscience | Catalog # 4247

Potent and selective mTOR inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective mTOR inhibitor
View all mTOR Inhibitors »

Product Description

Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. In HeLa cells, Torin 1 induces autophagy. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. In human monocytes and myeloid dendritic cells, Torin 1 prevents decreases the anti-inflammatory potency of glucocorticoids. In the human endocrine cell line BON, Torin 1 increases neurotensin secretion and gene expression through MEK/ERK/c-Jun pathway activation.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Product Specifications for Torin 1

Molecular Weight

607.62

Formula

C35H28F3N5O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one

CAS Number

1222998-36-8

PubChem ID

49836027

InChI Key

AKCRNFFTGXBONI-UHFFFAOYSA-N

SMILES

O=C(N5C6=CC(C(F)(F)F)=C(N7CCN(C(CC)=O)CC7)C=C6)C=CC2=C5C1=CC(C3=CN=C(C=CC=C4)C4=C3)=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.61 1 with gentle warming

Preparing Stock Solutions for Torin 1

The following data is based on the product molecular weight 607.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 164.58 mL 822.88 mL 1,645.77 mL
0.05 mM 32.92 mL 164.58 mL 329.15 mL
0.1 mM 16.46 mL 82.29 mL 164.58 mL
0.5 mM 3.29 mL 16.46 mL 32.92 mL

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Product Documents for Torin 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Torin 1

For research use only

Related Research Areas

Autophagy

Customer Reviews for Torin 1 (2)

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  • We got expected effect on cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary pancreatic ductal epithelial cells
    Verified Customer | Posted 04/03/2020
    0.076–500 nM Torin
    Torin 1 4247
  • inhibition of Torin in acute brain slices
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: acute brain slices
    Verified Customer | Posted 01/10/2018
    30 minute pre-incubation on acute slices
    We used Torin-1 to inhibit torin signalling, we got the expected effect on metabolic changes in acute brain slices

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