Torin 1

  ( 82 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4247
Chemical Name:1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Product Details
Citations (82)
Reviews
Biological Activity
Potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. Induces autophagy in HeLa cells.
Technical Data
  • M.Wt:
    607.62
  • Formula:
    C35H28F3N5O2
  • Solubility:
    Soluble to 1 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1222998-36-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Torin 1 include:

82 Citations: Showing 1 - 10
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  1. Tenovin-6 impairs autophagy by inhibiting autophagic flux.
    Authors: Yuan Et al.
    Cell Death Dis  2017;8:e2608
  2. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
    Authors: Sinha Et al.
    Autophagy  2017;13:169
  3. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
    Authors: Jennewein Et al.
    Oncotarget  2016;7:20016
  4. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
    Authors: Kimura Et al.
    Nature Communications  2016;7:13130
  5. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
    Authors: Gandin Et al.
    Nat Commun  2016;7:11127
  6. mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
    Authors: Pema Et al.
    Mol Biol Cell  2016;7:10786
  7. Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.
    Authors: Chen Et al.
    PLoS One  2016;6:28423
  8. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.
    Authors: Hao Et al.
    Proc Natl Acad Sci U S A  2016;5
  9. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets.
    Authors: Li Et al.
    Sci Adv  2016;2:e1601470
  10. Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy.
    Authors: Puente Et al.
    J Biol Chem  2016;291:6026
  11. RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy.
    Authors: Erbil Et al.
    J Biol Chem  2016;291:16753
  12. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.
    Authors: Saric Et al.
    Autophagy  2016;27:321
  13. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.
    Authors: Kobayashi Et al.
    J Immunol  2016;197:504
  14. Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.
    Authors: Contreras Et al.
    Biochim Biophys Acta  2016;1859:269
  15. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects.
    Authors: Zhang Et al.
    Cell Rep  2016;12:e1005848
  16. Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
    Authors: Bouche Et al.
    Autophagy  2016;12:484
  17. Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.
    Authors: Fernández Et al.
    Autophagy  2016;12:1487
  18. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.
    Authors: Pastore Et al.
    Autophagy  2016;12:1240
  19. IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.
    Authors: Bayraktar Et al.
    PLoS One  2016;11:e0164864
  20. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.
    Authors: Ma Et al.
    PLoS One  2016;11:e0156239
  21. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
    Authors: Holler Et al.
    Mol Neurodegener  2016;11:46
  22. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.
    Authors: Speranza Et al.
    Nat Chem Biol  2015;9:62
  23. The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process outgrowth in hypothalamic organotypic cultures.
    Authors: Askvig and Watt
    J Cell Commun Signal  2015;9:217
  24. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
    Authors: Chung Et al.
    Mol Cancer Res  2015;8:ra34
  25. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes.
    Authors: Sagnier Et al.
    J Virol  2015;89:615
  26. Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.
    Authors: Lee Et al.
    Neuron  2015;85:303
  27. Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation.
    Authors: Grassi Et al.
    Cell Death Dis  2015;6:e1880
  28. Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.
    Authors: Wong Et al.
    Nat Commun  2015;6:8048
  29. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes.
    Authors: Figueroa Et al.
    Autophagy  2015;67:966
  30. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
    Authors: Rebsamen Et al.
    Autophagy  2015;519:477
  31. Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1.
    Authors: Torres-Ayuso Et al.
    Oncogenesis  2015;4:e164
  32. Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy.
    Authors: Gubbiotti Et al.
    Matrix Biol  2015;48:14
  33. Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress.
    Authors: Ma Et al.
    Mol Cell Biol  2015;35:956
  34. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.
    Authors: Jung Et al.
    Mol Cell Biol  2015;35:2479
  35. HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders.
    Authors: Fields Et al.
    J Neurosci  2015;35:1921
  36. La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).
    Authors: Fonseca Et al.
    J Biol Chem  2015;290:15996
  37. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
    Authors: Toops Et al.
    J Exp Med  2015;26:41640
  38. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness.
    Authors: Yang Et al.
    J Clin Invest  2015;212:253
  39. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.
    Authors: Saqcena Et al.
    Autophagy  2015;14:2285
  40. A mechanism for asymmetric cell division resulting in proliferative asynchronicity.
    Authors: Dey-Guha Et al.
    Autophagy  2015;13:223
  41. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.
    Authors: Moon Et al.
    Cell Rep  2015;12:102
  42. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.
    Authors: Dasgupta Et al.
    Sci Signal  2015;125:1174
  43. Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication.
    Authors: Avey Et al.
    PLoS Pathog  2015;11:e1004993
  44. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
    Authors: Thorne Et al.
    Mol Biol Cell  2015;11:58
  45. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.
    Authors: Ito Et al.
    Nature  2015;11:547
  46. Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
    Authors: Newton Et al.
    Autophagy  2015;11:1594
  47. mTORC2 regulates cardiac response to stress by inhibiting MST1.
    Authors: Sciarretta Et al.
    Elife  2015;11:125
  48. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.
    Authors: Matsuzawa Et al.
    Sci Rep  2015;11:1052
  49. Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.
    Authors: Shi Et al.
    Front Behav Neurosci  2015;112:4678
  50. Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast.
    Authors: Ma Et al.
    PLoS One  2015;10:e0144677
  51. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.
    Authors: Li Et al.
    J Exp Med  2014;9:e104809
  52. Fertilization-induced autophagy in mouse embryos is independent of mTORC1.
    Authors: Yamamoto Et al.
    Biol Reprod  2014;91:7
  53. The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.
    Authors: Martina Et al.
    Sci Signal  2014;7:ra9
  54. Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.
    Authors: Valvezan Et al.
    Dis Model Mech  2014;7:63
  55. Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway.
    Authors: Hatanaka Et al.
    Diabetes  2014;63:3404
  56. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
    Authors: Liang Et al.
    J Exp Med  2014;211:2249
  57. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
    Authors: Li Et al.
    BMC Biochem  2014;211:15
  58. Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
    Authors: Zullo Et al.
    Proc Natl Acad Sci U S A  2014;15:4
  59. An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway.
    Authors: Su Et al.
    PLoS Pathog  2014;10:e1004196
  60. Development of a novel method for quantification of autophagic protein degradation by AHA labeling.
    Authors: Zhang Et al.
    PLoS Genet  2014;10:901
  61. Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids.
    Authors: Sahani Et al.
    Autophagy  2014;10:431
  62. Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF.
    Authors: Bernard Et al.
    Cell Cycle  2014;10:2193
  63. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes.
    Authors: Sharma Et al.
    Arthritis Rheumatol  2014;10:1637
  64. p53-directed translational control can shape and expand the universe of p53 target genes.
    Authors: Zaccara Et al.
    Cell Death Differ  2014;
  65. Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis.
    Authors: Xu Et al.
    Autophagy  2013;9:1418
  66. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    Nat Commun  2013;64:4361
  67. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.
    Authors: Bachar-Wikstrom Et al.
    Diabetes  2013;62:1227
  68. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.
    Authors: Kok Et al.
    J Lipid Res  2013;54:1662
  69. Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
    Authors: Francipane and Lagasse
    Oncotarget  2013;4:1948
  70. Epigenetic regulation of autophagy by the methyltransferase G9a.
    Authors: Narvajas Et al.
    Mol Cell Biol  2013;33:3983
  71. Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation.
    Authors: Fournier Et al.
    Mol Cell Biol  2013;33:2285
  72. Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.
    Authors: Li Et al.
    J Biol Chem  2013;288:35769
  73. mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.
    Authors: Dai Et al.
    Genes Dev  2013;27:301
  74. SYK regulates mTOR signaling in AML.
    Authors: Carnevale Et al.
    Leukemia  2013;27:2118
  75. mTOR regulates phagosome and entotic vacuole fission.
    Authors: Krajcovic Et al.
    Mol Biol Cell  2013;24:3736
  76. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.
    Authors: Zhou Et al.
    Cell Res  2013;23:508
  77. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.
    Authors: Gammoh Et al.
    Nat Struct Mol Biol  2013;20:144
  78. Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.
    Authors: Martina and Puertollano
    J Cell Biol  2013;200:475
  79. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
    Authors: Morita Et al.
    Cell Metab  2013;18:698
  80. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
    Authors: Martina Et al.
    Autophagy  2012;8:903
  81. Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.
    Authors: Fonseca Et al.
    J Biol Chem  2012;287:17530
  82. Keap1 degradation by autophagy for the maintenance of redox homeostasis.
    Authors: Taguchi Et al.
    J Exp Bot  2012;109:13561
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Species Mouse

Other Experimental Details

Other Experimental Details 30 minute pre-incubation on acute slices

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