TRAIP Antibody

Novus Biologicals | Catalog # NB100-1230

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all TRAIP Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-SLFQAKLDTFLWS corresponding to C-Terminus according to NP_005870.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for TRAIP Antibody

Immunohistochemistry-Paraffin: TRAIP Antibody [NB100-1230]

Immunohistochemistry-Paraffin: TRAIP Antibody [NB100-1230]

Immunohistochemistry-Paraffin: TRAIP Antibody [NB100-1230] - Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.

Applications for TRAIP Antibody

Application
Recommended Usage

Immunohistochemistry

4 - 6 ug/ml

Immunohistochemistry-Paraffin

4 - 6 ug/ml

Peptide ELISA

Detection limit 1:1000
Application Notes
Western Blot reactivity reported in scientific literature (PMID: 25335891).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TRAIP

The TNF receptor-associated factor (TRAF) family is a group of cytoplasmic adapter proteins that link a wide variety of cell surface receptors including the TNF and IL-1 receptor (TRNFR and IL-1R) superfamily to diverse signaling cascades involved in differentiation, proliferation, activation and apoptosis. TRIP (TRAF-interacting protein) was identified in 1997 as a component of receptor-TRAF signaling complexes (Lee, 1997). TRIP (also known as TRAIP) has been shown to associate with TRNFR2 or CD30 signaling complexes through its interaction with TRAF proteins and inhibit TRAF2-mediated NF-kB activation (Lee, 1997; Regamey et al, 2003). The recruitment of different TRAFs and TRAF associated proteins like TRIP to receptor complexes can help regulate and provide specificity to the intracellular signals triggered by the cell surface receptors.

Alternate Names

RNF206TRIPRING finger protein 206, TRAF interacting protein, TRAF-interacting protein

Entrez Gene IDs

10293 (Human)

Gene Symbol

TRAIP

UniProt

NP_005870.2 (Human)

Additional TRAIP Products

Product Documents for TRAIP Antibody

Certificate of Analysis

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Product Specific Notices for TRAIP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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