TumorTACS In Situ Apoptosis Detection Kit
TumorTACS In Situ Apoptosis Detection Kit Summary
Key Benefits
• Unique buffer system produces more consistent labeling.
• Performance tested on tumor samples.
• Includes both Proteinase K and exclusive non-enzymatic Cytonin permeabilization reagent.
• Includes TACS-Nuclease solution for preparing sample-dependent positive controls.
• Helps resolve unique problems encountered when using tissues or cells from tumors.
Why Use TumorTACS In Situ Apoptosis Detection Kit?
The labeling of tumor-containing specimens can be problematic due to the high levels of necrosis in these tissues. During necrosis, cessation of homeostasis, cell swelling, and nuclear membrane rupture generates highly degraded DNA that can interfere with interpretation of data.
Product Specifications
- In situ detection of apoptosis in fixed frozen, paraffin embedded, or plastic embedded cells and tissues.
- Assists in the identification of apoptotic morphologies.
Kit Contents
• Proteinase K
• Streptavidin-HRP
• Diaminobenzidine
• DAB Enhancer
• TACS-Nuclease
• TACS-Nuclease Buffer
• Methyl Green 1%
• TACS 2 TdT Labeling Buffer
• TACS 2 TdT Stop Buffer
• TACS 2 TdT dNTP
• TdT Enzyme
• 50x Manganese Cation
• Cytonin
Specifications
Limitations
For research use only. Not for diagnositic use.
Product Datasheets
Data Example
Apoptotic Cells within a Mouse Mammary Tumor Identified using the TumorTACS In Situ Apoptosis Detection Kit. Mammary tumor tissue was fixed in 4% paraformaldehyde overnight and paraffin-embedded. Five micron sections were prepared and placed onto glass microscope slides. The sample was processed following the TumorTACS Kit protocol (Catalog # 4815-30-K). Brown stained nuclei indicate apoptotic cells.
Citations for TumorTACS In Situ Apoptosis Detection Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2?+?murine breast cancer model
Authors: F Andreata, A Bonizzi, M Sevieri, M Truffi, M Monieri, L Sitia, F Silva, L Sorrentino, R Allevi, P Zerbi, B Marchini, E Longhi, R Ottria, S Casati, R Vanna, C Morasso, M Bellini, D Prosperi, F Corsi, S Mazzucchel
Sci Rep, 2020;10(1):11425. 2020
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Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer
Authors: SH Nam, JK Kim
Biomedicines, 2020;8(4):. 2020
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Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells
Authors: Y Tatsumi, M Miyake, K Shimada, T Fujii, S Hori, Y Morizawa, Y Nakai, S Anai, N Tanaka, N Konishi, K Fujimoto
Int J Mol Sci, 2020;21(11):. 2020
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Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression
Authors: SP Kalainayak, P Ghosh, S Dey, KE Fitzgerald, S Sohoni, PC Konduri, M Garrossian, L Liu, L Zhang
Sci Rep, 2019;9(1):1405. 2019
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Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma
Authors: X Liu, J Hu, X Song, K Utpatel, Y Zhang, P Wang, X Lu, J Zhang, M Xu, T Su, L Che, J Wang, M Evert, DF Calvisi, X Chen
Cancers (Basel), 2019;11(7):. 2019
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IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration
Authors: P Guha, R Tyagi, S Chowdhury, L Reilly, C Fu, R Xu, AC Resnick, SH Snyder
Cell Rep, 2019;26(10):2692-2703.e7. 2019
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Non-obstructive vas deferens and epididymis loss in cystic fibrosis rats
Authors: ZE Plyler, SE Birket, BD Schultz, JS Hong, SM Rowe, CF Petty, MR Crowley, DK Crossman, TR Schoeb, EJ Sorscher
Mech. Dev., 2019;155(0):15-26. 2019
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Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma.
Authors: Jain S, Stroopinsky D, Yin L, Rosenblatt J, Alam M, Bhargava P, Clark R, Kupper T, Palmer K, Coll M, Rajabi H, Pyzer A, Bar-Natan M, Luptakova K, Arnason J, Joyce R, Kufe D, Avigan D
Blood, 2015;126(3):354-62. 2015
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Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphoma.
Authors: Jain S, Jirau-Serrano X, Zullo K, Scotto L, Palermo C, Sastra S, Olive K, Cremers S, Thomas T, Wei Y, Zhang Y, Bhagat G, Amengual J, Deng C, Karan C, Realubit R, Bates S, O'Connor O
Clin Cancer Res, 2015;21(9):2096-106. 2015
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TNF-related apoptosis-inducing ligand enhances vinorelbine-induced apoptosis and antitumor activity in a preclinical model of non-small cell lung cancer.
Authors: Zhu K, Fang W, Chen Y, Lin S, Chen X
Oncol Rep, 2014;32(3):1234-42. 2014
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Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways.
Authors: Lin, Jiumao, Shen, Aling, Chen, Hongwei, Liao, Jun, Xu, Teng, Liu, Liya, Lin, Jing, Peng, Jun
BMC Cancer, 2014;14(0):729. 2014
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Distinct phospholipase C-beta isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.
Authors: Lee S, Leoni G, Neumann P, Chun J, Nusrat A, Yun C
Mol Cell Biol, 2013;33(10):2016-28. 2013
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Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production.
Authors: Chen TA, Wang JL, Hung SW, Chu CL, Cheng YC, Liang SM
PLoS ONE, 2011;6(8):e23317. 2011
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Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma.
Authors: Hua Y, White-Gilbertson S, Kellner J, Rachidi S, Usmani S, Chiosis G, Depinho R, Li Z, Liu B
Clin Cancer Res, 0;19(22):6242-51. 0
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Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma.
Authors: Barone T, Burkhart C, Safina A, Haderski G, Gurova K, Purmal A, Gudkov A, Plunkett R
Neuro Oncol, 0;19(2):186-196. 0
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Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection.
Authors: Martin F, McKie P, Cataliotti A, Sangaralingham S, Korinek J, Huntley B, Oehler E, Harders G, Ichiki T, Mangiafico S, Nath K, Redfield M, Chen H, Burnett J
Am J Physiol Regul Integr Comp Physiol, 0;302(2):R292-9. 0
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Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling.
Authors: Ter-Avetisyan G, Rathjen F, Schmidt H
J Neurosci, 0;34(3):737-47. 0
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Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells.
Authors: Liu Y, Sun S, Owonikoko T, Sica G, Curran W, Khuri F, Deng X
Mol Cancer Ther, 0;11(1):45-56. 0
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