Catalog Number: 4038
Chemical Name: N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
Biological Activity
Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
    Wang et al.
    J.Med.Chem., 2006;49:6139
  2. Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.
    Zeitlin et al.
    Cancer Res., 2006;66:8698
  3. TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis.
    Ashimori et al.
    Mol.Cancer.Ther., 2009;8:893
  4. TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway.
    Wang et al.
    Cancer Res., 2009;69:2757
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