Chemical Name: N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
Biological ActivityTW 37 is a Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Wang et al.
Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.
Zeitlin et al.
Cancer Res., 2006;66:8698
TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis.
Ashimori et al.
TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway.
Wang et al.
Cancer Res., 2009;69:2757
Citation for TW 37
The citations listed below are publications that use Tocris products. Selected citations for TW 37 include:
1 Citation: Showing 1 - 1
Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug FBT in VEGF-dependent angiosarcomas in vitro.
Authors: Majeed Et al.
Sci Rep 2019;9:6316
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