TW 37
Chemical Name: N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
Purity: ≥97%
Biological Activity
TW 37 is a Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Wang et al.
J.Med.Chem., 2006;49:6139 -
Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.
Zeitlin et al.
Cancer Res., 2006;66:8698 -
TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis.
Ashimori et al.
Mol.Cancer.Ther., 2009;8:893 -
TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway.
Wang et al.
Cancer Res., 2009;69:2757
Product Datasheets
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Citation for TW 37
The citations listed below are publications that use Tocris products. Selected citations for TW 37 include:
1 Citation: Showing 1 - 1
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Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug FBT in VEGF-dependent angiosarcomas in vitro.
Authors: Majeed Et al.
Sci Rep 2019;9:6316
FAQs
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