hh U 99194 maleate (CAS 234757-41-6): R&D Systems
Catalog Number: 1357
Alternate Names: PNU 99194
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate
Biological Activity
Potent, selective D3 antagonist. Ki values are 160, 2281 and > 10000 nM for human cloned D3, D2 and D4 receptors respectively.
Technical Data
  • M.Wt:
    393.48
  • Formula:
    C17H27NO2.C4H4O4
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    234757-41-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194.
    Audinot et al.
    J.Pharmacol.Exp.Ther., 1998;287:187
  2. Heterogeneity of behavioural profile between three putative selective D3 dopamine receptor antagonists using an ethologically based approach.
    Clifford and Waddington
    Psychopharmacology, 1998;136:284
  3. Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials.
    LaHoste et al.
    J.Neurosci., 2000;20:6666
Citations:

The citations listed below are publications that use Tocris products. Selected citations for U 99194 maleate include:

1 Citations: Showing 1 - 1

  1. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D 2 and D 3 Receptors
    Authors: Newton Et al.
    PLoS One 2016;11:e0158808

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