Catalog Number: 1765
Alternate Names: 3-CBW
Chemical Name: (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
Biological Activity
AMPA and kainate receptor antagonist. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres.
Technical Data
  • M.Wt:
    333.3
  • Formula:
    C15H15N3O6
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 25 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    544697-47-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists.
    More et al.
    Br.J.Pharmacol., 2003;138:1093
  2. The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.
    More et al.
    Br.J.Pharmacol., 2002;137:1125

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