Q: I'm looking Munc13-4 N terminal antibody with related epitope sequence.

A: Unfortunately we do not epitope map our antibodies, but we do have a whole list of antibodies against your target depending on species reactivity and application you want to use them for. Please see this link to our MUNC 13-4 antibodies. All of the immunogen information that is not proprietary, or known should be presented on the datasheet. Often times a range will be provided where the peptide falls within, or if it was raised against a larger recombinant protein as is the case for the one you inquired about we do not know exactly where the binding occurs.

UNC13D/Munc 13-4 Antibody

Novus Biologicals | Catalog # NB100-1434

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

View all UNC13D Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KQASQHALRPAP corresponding to C-Terminus according to NP_954712.1.

Localization

Cell Membrane and Cytoplasmic

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for UNC13D/Munc 13-4 Antibody

Immunohistochemistry-Paraffin: UNC13D/Munc 13-4 Antibody [NB100-1434]

Immunohistochemistry-Paraffin: UNC13D/Munc 13-4 Antibody [NB100-1434] - Staining of paraffin embedded human spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for UNC13D/Munc 13-4 Antibody

Application

Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml

Peptide ELISA

Detection limit 1:16000

Western Blot

1:100-1:2000

Application Notes

This antibody has been successfully used in Western blot in Human.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: UNC13D

Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion.

Long Name

UNC-13 Homolog D

Alternate Names

FHL3, HLH3, HPLH3, Munc13-4

Entrez Gene IDs

201294 (Human)

Gene Symbol

UNC13D

UniProt

NP_954712. (Human)

Additional UNC13D Products

Product Documents for UNC13D/Munc 13-4 Antibody

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Certificate of Analysis

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Product Specific Notices for UNC13D/Munc 13-4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Lysosomal Enzymes

Citations for UNC13D/Munc 13-4 Antibody

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