Chemical Name: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
Biological ActivityPositive allosteric modulator of GABAA receptors that displays preference for receptors containing β2 or β3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial agonist of 5-HT5A receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
Dietz et al.
Brain Res.Mol.Brain Res., 2005;138:191
GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts.
Benke et al.
Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity.
Khom et al.
Analysis of β-subunit-dependent GABAA receptor modulation and behavioral effects of valerenic acid derivatives.
Khom et al.
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