VDM 11

  ( 4 citations )    
Product Datasheet
Catalog Number:1392
Chemical Name:(5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide
Product Details
Citations (4)
Reviews
Biological Activity
A potent and selective inhibitor of the anandamide membrane transporter (AMT) with IC50 values of 4-11 μM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Ki values are > 5-10 μM at CB1 and CB2. Active in vivo. Also available in water-soluble emulsion (Cat. No. 1686).
Technical Data
  • M.Wt:
    409.61
  • Formula:
    C27H39NO2
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    313998-81-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for VDM 11 include:

4 Citations: Showing 1 - 4
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  1. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci  2010;32:1
  2. Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.
    Authors: Newman Et al.
    Eur J Neurosci  2007;25:1619
  3. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
    Authors: Hillard Et al.
    Br J Pharmacol  2007;152:691
  4. Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate.
    Authors: Battista Et al.
    Cereb Cortex  2002;1:1

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