Verapamil hydrochloride

Catalog # Availability Size / Price Qty
Verapamil hydrochloride | CAS No. 152-11-4 | Cav1.x Channel Blockers
1 Image
Description: CaV1.x blocker

Chemical Name: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride

Purity: ≥99%

Product Details
Citations (11)

Biological Activity

Verapamil hydrochloride is an L-type calcium channel blocker. Vasodilator and adrenergic antagonist. Verapamil induces autophagy by modulating cellular metabolism. Verapamil has been identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data

Soluble to 50 mM in water and to 50 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Verapamil hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Verapamil hydrochloride include:

11 Citations: Showing 1 - 10

  1. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  2. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
    Authors: Florea Et al.
    Oncotarget  2017;8:22876
  3. Chemerin-induced arterial contraction is Gi- and calcium-dependent.
    Authors: Ferland Et al.
    Vascul Pharmacol  2017;88:30
  4. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.
    Authors: Bragança Et al.
    Front Pharmacol  2016;7:45
  5. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    FEMS Immunol Med Microbiol  2015;6
  6. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    Cereb Cortex  2015;10:e0121634
  7. Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs.
    Authors: Dhillon Et al.
    PLoS One  2013;8:e60552
  8. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
    Authors: Chang Et al.
    PLoS One  2013;34:1096
  9. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.
    Authors: Xia Et al.
    Toxicol Appl Pharmacol  2011;252:250
  10. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
    Authors: Szikra Et al.
    PLoS One  2009;4:e6723


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