Catalog Number: 1160
Alternate Names: ET-1
Biological Activity
Endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.
Technical Data
  • M.Wt:
    2492
  • Formula:
    C109H159O32N25S5
  • Sequence:
    CSCSSLMDKECVYFCHLDIIW

    (Modifications: Disulfide bridge between 1 - 15, 3 - 11)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    117399-94-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
    Inoue et al.
    Proc.Natl.Acad.Sci.U.S.A., 1989;86:2863
  2. Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes.
    Servitja et al.
    Br.J.Pharmacol., 1998;124:1728
  3. Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide.
    Yanagisawa et al.
    Proc.Natl.Acad.Sci.U.S.A., 1988;85:6964
  4. Molecular biology and biochemistry of the endothelins.
    Yanagisawa and Masaski
    TiPS, 1989;10:374
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:

6 Citations: Showing 1 - 6
Filter your results:

  1. Endothelial cells enhance the migration of bovine meniscus cells.
    Authors: Yuan Et al.
    J Neurosci 2015;67:182
  2. The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow.
    Authors: Needham Et al.
    J Pharmacol Exp Ther 2014;55:2157
  3. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Invest Ophthalmol Vis Sci 2012;32:14489
  4. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol 2007;151:278
  5. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
    Authors: Khan Et al.
    Br J Pharmacol 2006;147:607
  6. Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
    Authors: Cirino Et al.
    Arthritis Rheumatol 2003;100:5531

Have you used Endothelin 1 (human, porcine)?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information