Endothelin 1 (human, porcine)
Biological ActivityEndothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.
(Modifications: Disulfide bridges 1-15, 3-11)
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The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Inoue et al.
Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes.
Servitja et al.
Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide.
Yanagisawa et al.
Molecular biology and biochemistry of the endothelins.
Yanagisawa and Masaski
Citations for Endothelin 1 (human, porcine)
The citations listed below are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:
16 Citations: Showing 1 - 10
The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.
Authors: Cheng Et al.
S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension.
Authors: Ban Et al.
Redox Biol 2019;21:101099
Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end-stage pulmonary hypertension with left heart disease.
Authors: Zhuang Et al.
Int J Mol Med 2018;42:1341
Dynamics and Functional Role of Dopaminergic Neurons in the Ventral Tegmental Area during Itch Processing.
Authors: Yuan Et al.
J Neurosci 2018;38:9856
Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy.
Authors: Zheng Et al.
Front Pharmacol 2017;8:222
IL-11 is a crucial determinant of cardiovascular fibrosis.
Authors: Schafer Et al.
Endothelial cells enhance the migration of bovine meniscus cells.
Authors: Yuan Et al.
J Neurosci 2015;67:182
The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow.
Authors: Needham Et al.
J Pharmacol Exp Ther 2014;55:2157
Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
Authors: Sánchez Et al.
Br J Pharmacol 2014;171:5682
UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes.
Authors: Bellono Et al.
J Gen Physiol 2014;143:203
Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
Authors: Hamby Et al.
Invest Ophthalmol Vis Sci 2012;32:14489
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
Authors: Suri Et al.
Br J Pharmacol 2010;159:566
Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway.
Authors: Giachini Et al.
Am J Physiol Heart Circ Physiol 2009;296:H489
Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
Authors: McQueen Et al.
Br J Pharmacol 2007;151:278
Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
Authors: Khan Et al.
Br J Pharmacol 2006;147:607
Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
Authors: Cirino Et al.
Arthritis Rheumatol 2003;100:5531
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VersaClone cDNA Plasmids
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