Endothelin 1 (human, porcine)

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Endothelin 1 (human, porcine)
1 Image
Description: Potent vasoconstrictor peptide
Alternative Names: ET-1

Purity: ≥95%

Product Details
Citations (16)
Supplemental Products

Biological Activity

Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.

Technical Data


(Modifications: Disulfide bridges 1-15, 3-11)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Endothelin 1 (human, porcine)

The citations listed below are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:

16 Citations: Showing 1 - 10

  1. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.
    Authors: Cheng Et al.
    Theranostics  2019;9:4287
  2. S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension.
    Authors: Ban Et al.
    Redox Biol  2019;21:101099
  3. Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end-stage pulmonary hypertension with left heart disease.
    Authors: Zhuang Et al.
    Int J Mol Med  2018;42:1341
  4. Dynamics and Functional Role of Dopaminergic Neurons in the Ventral Tegmental Area during Itch Processing.
    Authors: Yuan Et al.
    J Neurosci  2018;38:9856
  5. Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy.
    Authors: Zheng Et al.
    Front Pharmacol  2017;8:222
  6. IL-11 is a crucial determinant of cardiovascular fibrosis.
    Authors: Schafer Et al.
    Nature  2017;552:110
  7. Endothelial cells enhance the migration of bovine meniscus cells.
    Authors: Yuan Et al.
    J Neurosci  2015;67:182
  8. The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow.
    Authors: Needham Et al.
    J Pharmacol Exp Ther  2014;55:2157
  9. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
    Authors: Sánchez Et al.
    Br J Pharmacol  2014;171:5682
  10. UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes.
    Authors: Bellono Et al.
    J Gen Physiol  2014;143:203


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