Endothelin 1 (human, porcine)

  ( 11 citations )    
Product Datasheet
Catalog Number:1160
Alternate Names:ET-1
Chemical Name:
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
Endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.
Technical Data
  • M.Wt:
    2492
  • Formula:
    C109H159O32N25S5
  • Sequence:
    CSCSSLMDKECVYFCHLDIIW

    (Modifications: Disulfide bridge between 1 - 15, 3 - 11)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    117399-94-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:

11 Citations: Showing 1 - 10
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  1. Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy.
    Authors: Zheng Et al.
    Front Pharmacol  2017;8:222
  2. Endothelial cells enhance the migration of bovine meniscus cells.
    Authors: Yuan Et al.
    J Neurosci  2015;67:182
  3. The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow.
    Authors: Needham Et al.
    J Pharmacol Exp Ther  2014;55:2157
  4. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors.
    Authors: Sánchez Et al.
    Br J Pharmacol  2014;171:5682
  5. UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes.
    Authors: Bellono Et al.
    J Gen Physiol  2014;143:203
  6. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Invest Ophthalmol Vis Sci  2012;32:14489
  7. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
    Authors: Suri Et al.
    Br J Pharmacol  2010;159:566
  8. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway.
    Authors: Giachini Et al.
    Am J Physiol Heart Circ Physiol  2009;296:H489
  9. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol  2007;151:278
  10. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
    Authors: Khan Et al.
    Br J Pharmacol  2006;147:607
  11. Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
    Authors: Cirino Et al.
    Arthritis Rheumatol  2003;100:5531
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