Catalog Number: 1160
Alternate Names: ET-1
Biological Activity
Endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge between 1 - 15, 3 - 11)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
    Inoue et al.
    Proc.Natl.Acad.Sci.U.S.A., 1989;86:2863
  2. Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes.
    Servitja et al.
    Br.J.Pharmacol., 1998;124:1728
  3. Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide.
    Yanagisawa et al.
    Proc.Natl.Acad.Sci.U.S.A., 1988;85:6964
  4. Molecular biology and biochemistry of the endothelins.
    Yanagisawa and Masaski
    TiPS, 1989;10:374
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