Chemical Name: 3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide
Biological ActivityPositive allosteric modulator at mGlu1 (EC50 values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1 over mGlu4. Potentiates the decreased glutamate-induced calcium response in mGlu1 mutant cell models of schizophrenia.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.
Cho et al.
ACS Chem.Biol., 2014;9:2334
Citation for VU 0483605
The citations listed below are publications that use Tocris products. Selected citations for VU 0483605 include:
1 Citation: Showing 1 - 1
"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
Authors: Hellyer Et al.
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