Positive allosteric modulator at mGlu1
values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1
. Potentiates the decreased glutamate-induced calcium response in mGlu1
mutant cell models of schizophrenia.
Soluble to 50 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.
Cho et al.
ACS Chem.Biol., 2014;9:2334