VU 0483605

Catalog # Availability Size / Price Qty
5377/10
5377/50
Cat.No. 5377 - VU 0483605 | C20H10Cl3N3O3 | CAS No. 1623101-11-0
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Description: Positive allosteric modulator of mGlu1 receptors

Chemical Name: 3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide

Product Details
Citations (1)
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Biological Activity

Positive allosteric modulator at mGlu1 (EC50 values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1 over mGlu4. Potentiates the decreased glutamate-induced calcium response in mGlu1 mutant cell models of schizophrenia.

Technical Data

Formula:
C20H10Cl3N3O3
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1623101-11-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for VU 0483605

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