VX 702 (CAS 479543-46-9): R&D Systems
Catalog Number: 3916
Chemical Name: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
Biological Activity
Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (KD values are 3.7 and 17 nM respectively).
Technical Data
  • M.Wt:
    404.32
  • Formula:
    C19H12F4N4O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    479543-46-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.
    Din
    Curr.Opin.Investig.Drugs, 2006;7:1020
  2. Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
    Goldstein et al.
    J.Med.Chem., 2010;53:2345
  3. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis.
    Damjanov et al.
    Arthrit.Rheumat., 2009;60:1232
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VX 702 include:

1 Citations: Showing 1 - 1

  1. Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions inhuman astrocytes.
    Authors: O'Sullivan Et al.
    Journal of Neuroinflammation 2016;13:189

Have you used VX 702?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information