Catalog Number: 3916
Chemical Name: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
Biological Activity
Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (KD values are 3.7 and 17 nM respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.
    Curr.Opin.Investig.Drugs, 2006;7:1020
  2. Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
    Goldstein et al.
    J.Med.Chem., 2010;53:2345
  3. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis.
    Damjanov et al.
    Arthrit.Rheumat., 2009;60:1232

The citations listed below are publications that use Tocris products. Selected citations for VX 702 include:

Showing Results 1 - 1 of 1

  1. Fractalkine�shedding�is�mediated�by�p38�and the�ADAM10�protease�under�pro-inflammatory�conditions�inhuman�astrocytes.
    Authors: O'Sullivan Et al.
    Journal of Neuroinflammation
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information