Withaferin A

Catalog # Availability Size / Price Qty
2816/1
Withaferin A | CAS No. 5119-48-2 | NFkB/IkB Inhibitors
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Description: Inhibits NF-κB activation

Chemical Name: (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone

Purity: ≥98%

Product Details
Citations (7)
Reviews

Biological Activity

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.

Technical Data

M.Wt:
470.6
Formula:
C28H38O6
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
5119-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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