Chemical Name: (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
Biological ActivityWithaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Withaferin A is a potent inhibitor of angiogenesis.
Mohan et al.
The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry".
Yang et al.
Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity.
Kaileh et al.
Citations for Withaferin A
The citations listed below are publications that use Tocris products. Selected citations for Withaferin A include:
7 Citations: Showing 1 - 7
Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis.
Authors: Andersson Et al.
JCI Insight 2018;3
The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
Authors: Ryals Et al.
Front Cell Neurosci 2018;12:445
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
Authors: Yang Et al.
Neural Plast 2016;7:11385
Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.
Authors: Hatzold Et al.
Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes.
Authors: Martorana Et al.
EMBO J 2015;2015:381964
TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of AVNA.
Authors: Trendelenburg Et al.
Skelet Muscle 2012;2:3
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Authors: Yadav Et al.
J Mol Med (Berl) 2010;88:1243
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Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound
RAW macrophages were stimulated with Withaferin (1 µM) alone or in the presence of LPS (200 ng/ml) for 8 h to follow TNFalpha mRNA expression using qPCR. Withaferin significantly inhibited LPS-induced TNFalpha production.