Withaferin A

Catalog # Availability Size / Price Qty
2816/1
Withaferin A | CAS No. 5119-48-2 | NFkB/IkB Inhibitors
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Description: Inhibits NF-κB activation

Chemical Name: (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone

Purity: ≥98%

Product Details
Citations (7)
Reviews (2)

Biological Activity

Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.

Technical Data

M.Wt:
470.6
Formula:
C28H38O6
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
5119-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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42 perturbagens used the zebrafish DASPEI screen
By Anonymous on 12/17/2019
Application: Species: Other

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693

Withaferin inhibits LPS-induced TNFalpha production in macrophages
By Christopher Trummer on 10/22/2018
Application: Species: Mouse

RAW macrophages were stimulated with Withaferin (1 µM) alone or in the presence of LPS (200 ng/ml) for 8 h to follow TNFalpha mRNA expression using qPCR. Withaferin significantly inhibited LPS-induced TNFalpha production.


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