Withaferin A

  ( 5 citations )    
Product Datasheet
Catalog Number:2816
Chemical Name:(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
Product Details
Citations (5)
Reviews
Biological Activity
Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.
Technical Data
  • M.Wt:
    470.6
  • Formula:
    C28H38O6
  • Solubility:
    Soluble to 10 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    5119-48-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Withaferin A include:

5 Citations: Showing 1 - 5
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  1. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
    Authors: Yang Et al.
    Neural Plast  2016;7:11385
  2. Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.
    Authors: Hatzold Et al.
    Elife  2016;5
  3. Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes.
    Authors: Martorana Et al.
    EMBO J  2015;2015:381964
  4. TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A.
    Authors: Trendelenburg Et al.
    Skelet Muscle  2012;2:3
  5. Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
    Authors: Yadav Et al.
    J Mol Med (Berl)  2010;88:1243

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