WR 1065

Catalog # Availability Size / Price Qty
3356/10
3356/50
Cat.No. 3356 - WR 1065 | C5H14N2S.2HCl | CAS No. 14653-77-1
1 Image
Description: p53 activator. Also ROS scavenger

Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride

Product Details
Reviews

Biological Activity

Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.

Technical Data

M.Wt:
207.16
Formula:
C5H14N2S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
14653-77-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.
    North et al.
    Oncogene, 2000;19:1206
  2. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.
    Pluquet et al.
    J.Biol.Chem., 2003;278:11879
  3. WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication.
    Walker et al.
    Enviorn.Mol.Mutagen., 2009;50:460

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for WR 1065

There are currently no reviews for this product. Be the first to review WR 1065 and earn rewards!

Have you used WR 1065?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.