Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1
and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα
. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo
. Also exhibits broad spectrum antiviral activity in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.
North et al.
The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.
Pluquet et al.
WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication.
Walker et al.