Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
Biological ActivityWWL 113 is a carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
Dominguez et al.
Citation for WWL 113
The citations listed below are publications that use Tocris products. Selected citations for WWL 113 include:
1 Citation: Showing 1 - 1
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Authors: Patra Et al.
Nat Cell Biol 2018;20:811
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for WWL 113
There are currently no reviews for this product. Be the first to review WWL 113 and earn rewards!
Have you used WWL 113?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image