WWL 113

Catalog # Availability Size / Price Qty
5259/10
5259/50
Cat.No. 5259 - WWL 113 | C29H26N2O4 | CAS No. 947669-86-5
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Description: Ces3 and Ces1f inhibitor

Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester

Purity: ≥99%

Product Details
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Biological Activity

Carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

Technical Data

M.Wt:
466.53
Formula:
C29H26N2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
947669-86-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
    Dominguez et al.
    Nat.Chem.Biol., 2014;10:113

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