WWL 113

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5259/10
5259/50
WWL 113 | CAS No. 947669-86-5 | Hydrolase Inhibitors
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Description: Ces3 and Ces1f inhibitor

Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester

Product Details
Citations (1)
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Biological Activity

Carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

Technical Data

Formula:
C29H26N2O4
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
947669-86-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
    Dominguez et al.
    Nat.Chem.Biol., 2014;10:113

Product Datasheets

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