Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
Biological ActivityCarboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
Dominguez et al.
Citation for WWL 113
The citations listed below are publications that use Tocris products. Selected citations for WWL 113 include:
1 Citation: Showing 1 - 1
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Authors: Patra Et al.
Nat Cell Biol 2018;20:811
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