Carboxylesterase Ces3 and Ces1f inhibitor (IC50
values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.
Soluble to 50 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
Dominguez et al.