Catalog Number: 4194
Alternate Names: Desvenlafaxine
Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate
Biological Activity
Serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).
Technical Data
  • M.Wt:
    381.46
  • Formula:
    C16H25NO2.C4H6O4
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    448904-47-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats.
    Alfinito et al.
    Brain Res., 2006;1098:71
  2. Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor.
    Deecher et al.
    J.Pharmacol.Exp.Ther., 2006;318:657
  3. Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.
    Mason et al.
    J.Pharmacol.Exp.Ther., 2007;323:720

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