WY 45233 succinate
Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate
Biological ActivitySerotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Desvenlafaxine succinate: a new serotonin and NE reuptake inhibitor.
Deecher et al.
Desvenlafaxine succinate identifies novel antagonist binding determinants in the human NE transporter.
Mason et al.
Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and NE reuptake inhibitor desvenlaf. succinate in ovariectomized Sprague-Dawley rats.
Alfinito et al.
Brain Res., 2006;1098:71
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