XAB2 Antibody

Name: XAB2 Antibody
Brand: Novus Biologicals
SKU: NB100-794
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-794

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence C-SVPAAVFGSLKED corresponding to C-Terminus according to NP_064581.2.

Localization

Nuclear, detected in the splicing complex carrying pre-mRNA.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for XAB2 Antibody

Western Blot: XAB2 Antibody [NB100-794]

Western Blot: XAB2 Antibody [NB100-794] - NB100-794 staining (0.3ug/ml) of A431 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Immunohistochemistry-Paraffin: XAB2 Antibody [NB100-794]

Immunohistochemistry-Paraffin: XAB2 Antibody [NB100-794] - (3.8ug/ml) staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for XAB2 Antibody

Application

Recommended Usage

Immunohistochemistry

3 - 4 ug/ml

Immunohistochemistry-Paraffin

3 - 4 ug/ml

Peptide ELISA

Detection limit 1:8000

Western Blot

0.3 - 1 ug/ml

Application Notes

WB: Approx. 90 kDa band observed in human fibroblast A431 lysates (calculated MW of 100 kDa band according to NP_064581.2). IHC-P: Human brain (cerebral cortex) shows nuclear staining.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: XAB2

Tim50 is a component of the yeast Tim23 import machinery, which mediates translocation of presequence containing proteins across the mitochondrial inner membrane. By searching sequence databases, open reading frames encoding proteins with similarity to Tim50 and with a putative mitochondrial presequence were identified in the genomes of evolutionarily distant organisms, including human. Tim50 was found to interact with the N terminal intermembrane space domain of Tim23. Functional defects of Tim50 either by depletion of the protein or addition of anti Tim50 antibodies blocked the protein translocation across the inner membrane. A translocation intermediate accumulated at the translocator of the outer mitochondrial membrane (TOM) complex was cross linked to Tim50. Thus it can be concluded that Tim50, in cooperation with Tim23, facilitates transfer of the translocating protein from the TOM complex to the Tim23 complex.

Alternate Names

DKFZp762C1015, HCNPcrn-related protein kim1, HCRN, KIAA1177, NTC90, Protein HCNP, SYF1 homolog, RNA splicing factor, SYF1pre-mRNA-splicing factor SYF1, XPA binding protein 2, XPA-binding protein 2

Entrez Gene IDs

56949 (Human)

Gene Symbol

XAB2

UniProt

NP_064581.2 (Human)

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Product Specific Notices for XAB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for XAB2 Antibody

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