XD 14

Catalog # Availability Size / Price Qty
5489/10
5489/50
Cat.No. 5489 - XD 14 | C20H27N3O5S | CAS No. 1370888-71-3
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Description: BET bromodomain inhibitor

Chemical Name: 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide

Purity: ≥98%

Product Details
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Biological Activity

BET bromodomain inhibitor (Kd values are 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively). Also inhibits BRDT(1), CBP, p300 and BRDT(2) (Kd values are 1.2, 1.6, 2.6 and 3.7 μM respectively). Attenuates proliferation of HL-60 leukemia cells in vitro.

Technical Data

M.Wt:
421.51
Formula:
C20H27N3O5S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1370888-71-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
    Lucas et al.
    Angew.Chem.Int.Ed.Engl., 2013;52:14055

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