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XD 14

Catalog #: 5489 Datasheet / COA / SDS

Discontinued Product

5489 has been discontinued.
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XD 14 | CAS No. 1370888-71-3 | Bromodomain Inhibitors
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Description: BET bromodomain inhibitor

Chemical Name: 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide

Purity: ≥98%

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Biological Activity

BET bromodomain inhibitor (Kd values are 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively). Also inhibits BRDT(1), CBP, p300 and BRDT(2) (Kd values are 1.2, 1.6, 2.6 and 3.7 μM respectively). Attenuates proliferation of HL-60 leukemia cells in vitro.

Technical Data

M.Wt:
421.51
Formula:
C20H27N3O5S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1370888-71-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
    Lucas et al.
    Angew.Chem.Int.Ed.Engl., 2013;52:14055

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