(-)-Xestospongin C

Tocris Bioscience | Catalog # 1280

Reported inhibitor of IP3-dependent Ca2+ release
Tocris Bioscience

Key Product Details

Description

Reported inhibitor of IP3-dependent Ca2+ release

Alternative Names

XeC
View all Calcium Signaling Agents »

Product Description

(-)-Xestospongin C is a reported inhibitor of IP3-dependent Ca2+ release. Inhibits bradykinin-induced Ca2+ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells and shows no apparent interaction with the IP3 binding site. Other subsequent reports show (-)-Xestospongin C to be ineffective as an antagonist of IP3-evoked Ca2+ release in IP3 recepto- expressing DT40 cells. Cell permeable.

NOTE: (-)-Xestospongin C is typically used at a final concentration ranging from 0.5 to 10 μM. It is recommended to prepare stock solutions (10x to 100x) in DMSO or ethanol.

Product Specifications for (-)-Xestospongin C

Molecular Weight

446.71

Formula

C28H50N2O2

Storage

Store at -20°C

Chemical Name

(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine

CAS Number

88903-69-9

PubChem ID

9846431

InChI Key

PQYOPBRFUUEHRC-HCKQMYSWSA-N

SMILES

[H][C@]12[C@@H](CCCCCC[C@@H]3CCN(CCC[C@H]4CCCCCC5)[C@@]4([H])O3)CCCN1CC[C@@H]5O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 145 publications citing the usage of this product.

Product Documents for (-)-Xestospongin C

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (-)-Xestospongin C

For research use only

Citations for (-)-Xestospongin C

Customer Reviews for (-)-Xestospongin C (3)

4.7 out of 5
3 Customer Ratings
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  • test
    Name: Mohammad Alqudah
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Smooth muscle
    Verified Customer | Posted 10/19/2022
    Used to inhibit IP3 receptors in smooth muscle strips in an organ bath at 10 uM
    (-)-Xestospongin C 1280
  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Verified Customer | Posted 12/03/2019
    Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail - 1 umol/L
    (-)-Xestospongin C 1280
  • Blocker of IP3 channels
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 05/19/2019
    We used (-)-Xestospongin C (XeC) to block calcium release from endoplasmic reticulum via IP3 channels in presynaptic neurons. As a result, LPI, agonist of GPR55 receptor, failed to induce an increase of neurotransmitter release, since this process is calcium-dependent. As a sequence, after application of XeC there was no augmentation of the amplitude of evoked post-synaptic response in postsynaptic neuron: see image.
    (-)-Xestospongin C 1280

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