(-)-Xestospongin C

Catalog # Availability Size / Price Qty
1280/10U
(-)-Xestospongin C | CAS No. 88903-69-9 | Calcium Signaling Agents
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Description: Reported inhibitor of IP3-dependent Ca2+ release
Alternative Names: XeC

Chemical Name: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine

Product Details
Citations (14)
Reviews (1)

Biological Activity

Reported inhibitor of IP3-dependent Ca2+ release. Inhibits bradykinin-induced Ca2+ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Does not interact with the IP3 binding site. Recently shown to be an ineffective antagonist of IP3-evoked Ca2+ release in IP3 receptor expressing DT40 cells. Cell permeable.

Technical Data

M.Wt:
446.71
Formula:
C28H50N2O2
Solubility:
Soluble to 2 mM in DMSO and to 2 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
88903-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (-)-Xestospongin C

The citations listed below are publications that use Tocris products. Selected citations for (-)-Xestospongin C include:

14 Citations: Showing 1 - 10

  1. A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel.
    Authors: Chen Et al.
    Front Endocrinol (Lausanne)  2018;9:721
  2. A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.
    Authors: Hellmer Et al.
    Physiol Rep  2018;6:e13885
  3. Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
    Authors: Lim Et al.
    Int J Mol Sci  2018;19
  4. WNT5a is required for normal ovarian follicle development and antagonizes g.tropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
    Authors: Abedini Et al.
    FASEB J  2016;30:1534
  5. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    Endocrinology  2015;6
  6. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  7. Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice.
    Authors: Glanowska and Moenter
    Cell Rep  2015;156:231
  8. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
    Authors: Oh Et al.
    FASEB J  2015;10:162
  9. The role of the hypothalamic paraventricular nucleus and the organum vasculosum lateral terminalis in the control of sodium appetite in male rats.
    Authors: Grafe Et al.
    J Neurosci  2014;34:9249
  10. Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
    Authors: Nordman and Kabbani
    J Neurosci  2014;28:2995

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Blocker of IP3 channels
By Sergiy Sylantyev on 05/19/2019
Species: Rat

We used (-)-Xestospongin C (XeC) to block calcium release from endoplasmic reticulum via IP3 channels in presynaptic neurons. As a result, LPI, agonist of GPR55 receptor, failed to induce an increase of neurotransmitter release, since this process is calcium-dependent. As a sequence, after application of XeC there was no augmentation of the amplitude of evoked post-synaptic response in postsynaptic neuron: see image.

PMID: 23472002

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