Chemical Name: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
Biological Activity(-)-Xestospongin C is a reported inhibitor of IP3-dependent Ca2+ release. Inhibits bradykinin-induced Ca2+ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Does not interact with the IP3 binding site. Recently shown to be an ineffective antagonist of IP3-evoked Ca2+ release in IP3 receptor expressing DT40 cells. Cell permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation.
Dadsetan et al.
Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.
Gafni et al.
Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.
Saleem et al.
Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle.
Ozaki et al.
Citations for (-)-Xestospongin C
The citations listed below are publications that use Tocris products. Selected citations for (-)-Xestospongin C include:
15 Citations: Showing 1 - 10
Cross-talk Between CD38 and TTP Is Essential for Resolution of Inflammation During Microbial Sepsis.
Authors: Joe Et al.
Cell Rep 2020;30:1063
A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel.
Authors: Chen Et al.
Front Endocrinol (Lausanne) 2018;9:721
A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.
Authors: Hellmer Et al.
Physiol Rep 2018;6:e13885
Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
Authors: Lim Et al.
Int J Mol Sci 2018;19
WNT5a is required for normal ovarian follicle development and antagonizes g.tropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
Authors: Abedini Et al.
FASEB J 2016;30:1534
Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
Authors: Azab Et al.
Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
Authors: Tabatadze Et al.
J Neurosci 2015;35:11252
Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice.
Authors: Glanowska and Moenter
Cell Rep 2015;156:231
Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
Authors: Oh Et al.
FASEB J 2015;10:162
The role of the hypothalamic paraventricular nucleus and the organum vasculosum lateral terminalis in the control of sodium appetite in male rats.
Authors: Grafe Et al.
J Neurosci 2014;34:9249
Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
Authors: Nordman and Kabbani
J Neurosci 2014;28:2995
UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes.
Authors: Bellono Et al.
J Gen Physiol 2014;143:203
Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
Authors: Oh Et al.
Proc Natl Acad Sci U S A 2013;110:E305
The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins.
Authors: Belal Et al.
Hum Mol Genet 2012;21:963
The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
Authors: Xu Et al.
Am J Physiol Renal Physiol 2011;31:17074
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Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail - 1 umol/L
We used (-)-Xestospongin C (XeC) to block calcium release from endoplasmic reticulum via IP3 channels in presynaptic neurons. As a result, LPI, agonist of GPR55 receptor, failed to induce an increase of neurotransmitter release, since this process is calcium-dependent. As a sequence, after application of XeC there was no augmentation of the amplitude of evoked post-synaptic response in postsynaptic neuron: see image.