(-)-Xestospongin C

  ( 10 citations )    
Product Datasheet
Catalog Number:1280
Alternate Names:XeC
Chemical Name:(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
Product Details
Citations (10)
Reviews
Biological Activity
Reported inhibitor of IP3-dependent Ca2+ release. Inhibits bradykinin-induced Ca2+ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Does not interact with the IP3 binding site. Recently shown to be an ineffective antagonist of IP3-evoked Ca2+ release in IP3 receptor expressing DT40 cells. Cell permeable.
Technical Data
  • M.Wt:
    446.71
  • Formula:
    C28H50N2O2
  • Solubility:
    Soluble to 2 mM in DMSO and to 2 mM in ethanol
  • Storage:
    Desiccate at -20°C
  • CAS No:
    88903-69-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Xestospongin C include:

10 Citations: Showing 1 - 10
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  1. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
    Authors: Abedini Et al.
    FASEB J  2016;30:1534
  2. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    Endocrinology  2015;6
  3. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  4. Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice.
    Authors: Glanowska and Moenter
    Cell Rep  2015;156:231
  5. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
    Authors: Oh Et al.
    FASEB J  2015;10:162
  6. Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
    Authors: Nordman and Kabbani
    J Neurosci  2014;28:2995
  7. UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes.
    Authors: Bellono Et al.
    J Gen Physiol  2014;143:203
  8. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
    Authors: Oh Et al.
    Proc Natl Acad Sci U S A  2013;110:E305
  9. The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins.
    Authors: Belal Et al.
    Hum Mol Genet  2012;21:963
  10. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
    Authors: Xu Et al.
    Am J Physiol Renal Physiol  2011;31:17074

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