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Y-27152

2077 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2077/10
2077/50
Y-27152 | CAS No. 127408-30-4 | Inward Rectifier Potassium Channel Activators
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Description: Prodrug of Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076); orally active in vivo

Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide

Purity: ≥98%

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Biological Activity

Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Technical Data

M.Wt:
366.41
Formula:
C21H22N2O4
Solubility:
Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
127408-30-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Y-26763

2076
1 Review
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Product was used on Kir2.2 channels to understand channel modulation
By Anonymous on 11/29/2018
Application: Species: Human

Y-27152 ws used on Kir2.2 channels expressed on human brain cells to understand channel modulation at increasing concentrations.

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