Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
Biological ActivityProdrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
Nakajima et al.
Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels.
Fukunari et al.
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Y-27152 ws used on Kir2.2 channels expressed on human brain cells to understand channel modulation at increasing concentrations.