Y-27152
Discontinued Product
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
Purity: ≥98%
Biological Activity
Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
Nakajima et al.
J.Pharmacol.Exp.Ther., 1992;261:730 -
Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels.
Fukunari et al.
Eur.J.Pharmacol., 1997;323:197
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Y-27152 ws used on Kir2.2 channels expressed on human brain cells to understand channel modulation at increasing concentrations.
