Catalog Number: 3278
Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile
Biological Activity
Orally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).
Technical Data
  • M.Wt:
    354.2
  • Formula:
    C16H12BrN5
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    148869-05-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
(Sold with the permission of Astellas Pharma Inc.)
Background References
  1. Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives.
    Okada et al.
    Chem.Pharm.Bull., 1996;44:1871
  2. The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511.
    Kudoh et al.
    J.Steroid Biochem.Molec.Biol., 1995;54:265

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