YM 511

Catalog # Availability Size / Price Qty
3278/10
3278/50
YM 511 | CAS No. 148869-05-0 | Cytochrome P450 Inhibitors
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Description: Potent aromatase (CYP19) inhibitor

Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile

Purity: ≥99%

Product Details
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Biological Activity

Orally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).

Technical Data

M.Wt:
354.2
Formula:
C16H12BrN5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
148869-05-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
(Sold with the permission of Astellas Pharma Inc.)

Background References

  1. Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives.
    Okada et al.
    Chem.Pharm.Bull., 1996;44:1871
  2. The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511.
    Kudoh et al.
    J.Steroid Biochem.Molec.Biol., 1995;54:265
  3. Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell.
    Kudoh et al.
    J.Steroid Biochem.Molec.Biol., 1996;58:189

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