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Uptake of Amyloid beta by Macrophages

Amyloid beta (A-beta) peptides are the main component of senile plaques and are involved in the development of Alzheimer’s disease (AD). Cells in the brain continuously produce and secrete A-beta peptides, thus they need to be cleared in order to prevent accumulation. In addition to microglia, peripheral macrophages also play a role in the elimination of A-beta from the brain via its uptake and subsequent degradation. In fact, research has suggested that infiltrating macrophages may be the primary cells responsible for the phagocytosis and degradation of A-beta. Additionally, peripheral macrophages may contribute to the etiology of AD because studies have shown that macrophages isolated from individuals with AD are poorly phagocytic for A-beta and are more susceptible to apoptosis. R&D Systems offers a range of research tools needed for investigating the clearance of A-beta by macrophages.