6 results for "5-HT1 Receptor Agonists Small Molecules and Peptides" in Products
5-HT1 Receptor Agonists Small Molecules and Peptides
The serotonin 5-HT1A receptor was the first 5-HT receptor to be fully sequenced and the human gene encoding this receptor has been localized to chromosome 5 (5q11.2-q13).
5-HT1A receptor binding sites are located primarily in limbic brain areas, notably the hypothalamus, lateral septum, cortical areas and the mesencephalic raphe nuclei. 5-HT1A receptor ligands with agonist activity possess antianxiety, antidepressant, antiaggressive, and perhaps anticraving, anticataleptic, antiemetic, and neuroprotective properties.
5-HT1A, 5-HT1B and 5-HT1D agonist
| Alternate Names: | GR 43175 |
| Chemical Name: | 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate |
| Purity: | ≥99% |
5-HT1A and 5-HT1B agonist
| Chemical Name: | 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate |
| Purity: | ≥99% |
Highly potent D2-like antagonist; also 5-HT1A agonist
| Alternate Names: | YM 09151,YM 09151-2 |
| Chemical Name: | cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide |
| Purity: | ≥98% |
Selective 5-HT1A agonist
| Alternate Names: | TVX Q 7821 |
| Chemical Name: | 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide |
| Purity: | ≥99% |
Selective 5-HT1A partial agonist
| Alternate Names: | SM-3997 |
| Chemical Name: | (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥98% |
High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
| Chemical Name: | 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone |
| Purity: | ≥99% |
