103 results for "DYRK2" in Products

DYRK2 Products

DYRK2 (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 2) is a member of the MNB/DYRK subfamily, CMGC Ser/Thr protein kinase family of enzymes. DYRK2 is expressed in multiple tissues and shows dual substrate specificity. Autophosphorylation on Tyr382 leads to self-activation, while target proteins are Ser/Thr phosphorylated. Targets include NFATc, glycogen synthase, and p53. p53 phosphorylation on Ser46 by DYRK2 leads to cell apoptosis in response to DNA damage. Human DYRK2 is 601 amino acids (aa) in length, and contains one kinase catalytic domain (aa 222-535).

Potent and selective DYRK inhibitor; orally bioavailable.

Chemical Name: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
Purity: ≥95%
Potent and selective DYRK inhibitor; orally bioavailable.
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Reactivity: Human
Details: Mouse IgG3 Kappa Monoclonal Clone #6E2
Applications: WB, ELISA, ICC/IF
Western Blot: DYRK2 Antibody (6E2) [H00008445-M02]
(2)
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Reactivity: Human
Source: Wheat germ
Applications: WB, ELISA, AP, Enzyme Activity, MA
SDS-PAGE: Recombinant Human DYRK2 GST (N-Term) Protein [H00008445-P01]
(2)
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Reactivity: Human
Details: Mouse IgG2a Kappa Monoclonal Clone #3G5
Applications: WB, ELISA
Western Blot: DYRK2 Antibody (3G5) [H00008445-M01]
(2)
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Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: ICC/IF
Immunocytochemistry/ Immunofluorescence: DYRK2 Antibody [NBP2-58747]
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Reactivity: Human
Details: Mouse IgG1 kappa Monoclonal Clone #4G11
Applications: WB, ELISA
Western Blot: DYRK2 Antibody (4G11) [H00008445-M03]
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