MICL is a member of the group V subfamily of the C-type lectin-like family of molecules. It is found on the cell surface, contains an ITIM (immunoreceptor tyrosine-based inhibitory motif) in its cytoplasmic domain, and is N-glycosylated. Expression of MICL is restricted to granulocytes and monocytes, and it may function as a negative regulator of these cell types. At least three isoforms of MICL are generated by alternative splicing, including one that lacks the transmembrane domain.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.