Human MICL/CLEC12A Antibody (687317)

R&D Systems | Catalog # MAB2946

Clone 687317 was used by HLDA to establish CD designation
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Flow Cytometry, CyTOF-ready

Cited:

Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 687317
View all MICL/CLEC12A Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human MICL/CLEC12A
Thr67-Ala265
Accession # Q5QGZ9

Specificity

Detects human MICL/CLEC12A in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) CLEC1, 2, 2A, 3B, 9A, 10A, 12B, 14A, rhCD302/CLEC13A recombinant mouse (rm) CLEC4B2, or rmMICL is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human MICL/CLEC12A Antibody (687317)

Detection of MICL/CLEC12A antibody in Human Peripheral Blood Granulocytes antibody by Flow Cytometry.

Detection of MICL/CLEC12A in Human Peripheral Blood Granulocytes by Flow Cytometry.

Human peripheral blood granulocytes were stained with Mouse Anti-Human MICL/CLEC12A Monoclonal Antibody (Catalog # MAB2946, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).

Applications for Human MICL/CLEC12A Antibody (687317)

Application
Recommended Usage

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

2.5 µg/106 cells
Sample: Human peripheral blood granulocytes

Reviewed Applications

Read 1 review rated 5 using MAB2946 in the following applications:

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Sterile PBS to a final concentration of 0.5 mg/mL. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: MICL/CLEC12A

Human MICL (myeloid inhibitory C-type lectin-like receptor; also CLL-1 and KLRL-1) is a 75 kDa member of the group V C-type lectin-like receptor family of molecules. Group V molecules have a lectin-type domain that binds non-sugar ligands. MICL is a 265 amino acid (aa) type II transmembrane (TM) glycoprotein that contains a 200 aa extracellular domain (ECD). Multiple isoforms of MICL are reported. One potentially utilizes an alternate start site that adds 10 aa to the cytoplasmic domain. There is one potential soluble form that lacks the TM segment, and two truncated ECD isoforms. Human MICL ECD is 53%, 65%, and 55% aa identical to the ECD in mouse, dog and cow, respectively.

Long Name

Myeloid Inhibitory C-type Lectin-like Receptor

Alternate Names

CD371, CLEC12A, CLL-1, DCAL-2

Entrez Gene IDs

160364 (Human); 232413 (Mouse)

Gene Symbol

CLEC12A

UniProt

Q5QGZ9

Additional MICL/CLEC12A Products

Product Documents for Human MICL/CLEC12A Antibody (687317)

Certificate of Analysis

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Product Specific Notices for Human MICL/CLEC12A Antibody (687317)

For research use only

Citations for Human MICL/CLEC12A Antibody (687317)

Customer Reviews for Human MICL/CLEC12A Antibody (687317) (1)

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Customer Images

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  • Binding of CLEC12A in M2c macrophages
    Name: Anonymous
    Application: Flow Cytometry
    Sample Tested: Human macrophages
    Species: Human
    Verified Customer | Posted 06/20/2026
    Binding of CLEC12A in M2c macrophages. The cells were incubated with a titration of the human CLEC12A antibody or isotype control for 30 minutes on ice, followed by a secondary a-mouse IgG APC
    The antibody was tested for binding to CLEC12A expressed in human monocyte-derived macrophages. The antibody was titrated starting at 100 nM and detected with a secondary a-mouse IgG APC at 1:300 dilution
    Human MICL/CLEC12A Antibody (687317) MAB2946

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