8 results for "NPY Receptor Antagonists Small Molecules and Peptides" in Products

NPY Receptor Antagonists Small Molecules and Peptides

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.

All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

Highly selective and potent non-peptide NPY Y5 receptor antagonist

Chemical Name: N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride
Purity: ≥98%
Highly selective and potent non-peptide NPY Y5 receptor antagonist
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Highly selective NPY Y1 receptor antagonist

Chemical Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate
Purity: ≥98%
Highly selective NPY Y1 receptor antagonist
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Mixed NPY Y1 and NPFF receptor antagonist

Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate
Purity: ≥98%
Mixed NPY Y1 and NPFF receptor antagonist
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Potent, selective non-peptide NPY Y5 receptor antagonist

Chemical Name: 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione
Purity: ≥98%
Potent, selective non-peptide NPY Y5 receptor antagonist
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NPY Y2 receptor antagonist

Chemical Name: N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity: ≥98%
NPY Y2 receptor antagonist
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Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo

Alternate Names: BIIE 0246 2HCl,BIIE0246 2HCl
Chemical Name: N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride
Purity: ≥98%
Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo
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Potent NPY Y5 receptor antagonist

Chemical Name: N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
Purity: ≥98%
Potent NPY Y5 receptor antagonist
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Potent NPY Y2 receptor antagonist

Chemical Name: N-[4-[(Dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity: ≥98%
Potent NPY Y2 receptor antagonist
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