7 results for "RAR gamma/NR1B3 Small Molecules and Peptides" in Products
RAR gamma/NR1B3 Small Molecules and Peptides
Retinoids can reverse various premalignant lesions as well as prevent some second primary tumors. The effects of retinoids are regulated by retinoic acid receptors (RAR) and retinoid X receptors, which act as ligand-activated transcription factors. Ligand-dependent transcriptional activation of RARs is a multistep process that ends with the formation of a multimeric co-activator complex on regulated promoters. Retinoic acid receptor gamma has been shown to be the most important retinoid receptor for regulation of retinoic acid turnover rate and retinoic acid induced growth inhibition. While RAR mRNA levels may be useful biomarkers for various diseases, RAR gamma expression is decreased in Barrett's tissues compared with normal tissue.
High affinity pan-RAR antagonist
| Chemical Name: | 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid |
| Purity: | ≥98% |
Retinoic acid analog; RARα agonist
| Chemical Name: | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid |
| Purity: | ≥98% |
Potent RAR agonist
| Chemical Name: | 4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid |
| Purity: | ≥98% |
Blocks retinoic acid metabolism
| Alternate Names: | R-75251 |
| Chemical Name: | 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride |
| Purity: | ≥98% |
Synthetic retinoid; induces differentiation of stem cells
| Chemical Name: | 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid |
| Purity: | ≥99% |
Selective RARγ agonist
| Chemical Name: | 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid |
| Purity: | ≥95% |
Potent and selective RARγ agonist
| Chemical Name: | 4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid |
| Purity: | ≥98% |
