S100A4 Products

Mouse S100 calcium-binding protein A4 (S100A4; also metastasin, mts1, metastatic cell protein, and placental calcium-binding protein) is a 12 kDa member of the S100 family of calcium-binding proteins. S100A4 is 101 amino acids (aa) in length and contains two calcium-binding EF-hand domains (aa 12 - 47 and 50 - 85). Mouse S100A4 shares 96%, 93%, and 90% aa sequence identity with rat, human, and bovine S100A4, respectively. S100A4 is involved in regulating the metastatic behavior of tumor cells. It is ubiquitously expressed in tumor cells and normal cells, but the level of S100A4 expression correlates with the metastatic potential of tumor cells.