Blogs for December 2017

Webinar Short: B7-related Butryophilins as Immune Modulators

Tuesday, December 26, 2017 - 08:41

A short description of Butyrophilin proteins produced by R&D Systems. These B7-related proteins may be checkpoint targets.

Butyrophilin Products

Recorded December 22, 2017

Neuroscience Research Review: Neuronal EphB1 Activates a Neuroprotective Astrocyte Phenotype

Friday, December 15, 2017 - 08:36
Neuroprotective Astrocytes Induced by Neuronal EphB1

In the central nervous system (CNS), glia are key for maintaining tissue homeostasis. They function to support numerous processes including neurogenesis and neuronal survival, neural transmission, and immune surveillance. They also play a role in the initiation and progression of neuroinflammation and neurodegenerative disease. Astrocytes, the most abundant glial cell in the CNS, become activated in response to many insults, such as trauma, stroke, or neurodegenerative disease.1 Astrogliosis appears to be a complicated process as research is showing that the phenotype of reactive astrocytes may be defined by...

20 Years and Getting Stronger – The Ins and Outs of SUMOylation

Tuesday, December 12, 2017 - 16:35

Posttranslational modification with Small Ubiquitin-related Modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly and protein homeostasis, trafficking and signal transduction are subject to reversible sumoylation. It is hence not surprising that disease links are beginning to emerge and that interference with sumoylation is being considered for intervention. In this webinar, Dr. Frauke Melchior provides an overview of fundamental mechanisms and highlight recent developments in the analysis and physiology of sumoylation.


RNAScope® Technology Hits 1000 Publications

Wednesday, December 6, 2017 - 07:49
Bio-Techne’s RNAScope

Bio-Techne’s RNAScope® Technology Hits 1000 Publications!

Bio-Techne is celebrating an exciting milestone for our RNAScope® assays from the Advanced Cell Diagnostics brand: 1000 publications citing the use of RNAScope® in situ hybridization (ISH) technology! We have announced this milestone in a press release on November 28, 2017.

With 400 of these publications in 2017 alone, this surge includes a notable increase in the use of the RNAScope technology in the pharmaceutical and biotechnology industries. This increase highlights awareness of the robust, sensitive, and specific ISH assay by...

Intestinal Lamina Propria Cell Markers

Monday, December 4, 2017 - 16:31
Intestinal Lamina Proprial Cell Markers

R&D Systems Cell Marker Pages: The Easiest Way to Plan Your Next Experiment

One of the challenges of moving into a new research field or expanding your current field of study is determining the best markers to identify the cells you want. R&D Systems has been providing researchers with reliable tools for defining cell populations for over 30 years. Now we’ve added new Cell Marker Tools for Mucosal Immunity, Atherosclerosis, and Asthma on our website!


Quarterly Protein Product and Data Update: Edition #3

Monday, December 4, 2017 - 12:26
Protein Structure Banner

New Products

recombinant GFRAL
GFRAL: The Receptor that Mediates the Metabolic Function of GDF-15 is Identified
Several high-profile papers have recently identified GFRAL as a receptor mediating GDF-15 effects on obesity and insulin resistance. R&D Systems’ new Recombinant Human GFRAL binds GDF-15 with an ED50 in the sub ng/mL range....

Stem Cells in the News - December 2017

Monday, December 4, 2017 - 12:12
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

Science Daily

A team of researchers at Fred Hutchinson Cancer Research Center have identified a single, specific subset of adult stem cells that are...

RAS Oncoproteins: Therapeutic Vulnerabilities

Friday, December 1, 2017 - 14:05

Adrienne Cox, Ph.D. Associate Professor, UNC Chapel Hill

The three human RAS↗ genes (HRAS↗, KRAS↗ and NRAS↗) encode four highly related RAS small GTPases↗ (HRAS, KRAS4A, KRAS4B and NRAS). RAS proteins function as GDP-GTP regulated binary on-off switches that regulate diverse cytoplasmic signaling networks. In cancer and developmental disorders (RASopathies), mutationally activated RAS proteins drive aberrant signal transduction. RAS proteins are also the founding...