Human HLA-DR PE-conjugated Antibody

FAB4869P 3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB4869P-100
FAB4869P-025

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Human HLA-DR PE-conjugated Antibody in Data

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Citations (3)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human HLA-DR PE-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human HLA‑DR.

Source

Monoclonal Mouse IgG₁ Clone # L203

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

RPMI 8866 human lymphoblastoid cells
Accession # P01903

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry

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Detection of HLA‑DR in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human HLA-DR PE-conjugated Monoclonal Antibody (Catalog # FAB4869P) or (B) isotype control antibody (Catalog # IC002P) and Mouse anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: HLA-DR

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member and consists of a 34 kDa (alpha) subunit and one of several 28 kDa (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4⁺ T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer.

Long Name

Major Histocompatibility Complex Class II DR

Entrez Gene IDs

3122 (Human)

Alternate Names

FLJ51114; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLADR; HLA-DR; HLA-DRA; HLA-DRA1; major histocompatibility complex, class II, DR alpha; MHC cell surface glycoprotein; MHC class II antigen DRA; MHC Class II DR; MLRW

Product Datasheets

Product Datasheet

COA

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Related Research Areas

Citations for Human HLA-DR PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
J Clin Invest, 2016;126(8):3130-44.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission.
Authors: Beck B, Dorfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M
J Transl Med, 2011;9(0):151.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Eosinophils induce DC maturation, regulating immunity.
Authors: Lotfi R, Lotze MT
J. Leukoc. Biol., 2007;83(3):456-60.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry