Human HLA-DR PerCP-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB4869C-100
FAB4869C-025
Human HLA-DR PerCP-conjugated Antibody in Data
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Product Details
Citations (3)
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Human HLA-DR PerCP-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human HLA‑DR.
Source
Monoclonal Mouse IgG1 Clone # L203
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
RPMI 8866 human lymphoblastoid cells
Accession # P01903
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
PerCP (Excitation= nm, Emission= nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of HLA-DR in Human Blood Lymphocytes by Flow Cytometry. View Larger

Detection of HLA-DR in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human HLA-DR PerCP-conjugated Monoclonal Antibody (Catalog # FAB4869C) or (B) isotype control antibody (Catalog # IC002C) and Mouse anti-Human CD19 CFS-conjugated Monoclonal Antibody (Catalog # FAB4867F). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: HLA-DR

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member and consists of a 34 kDa (alpha) subunit and one of several 28 kDa (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4+ T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer.

Long Name
Major Histocompatibility Complex Class II DR
Entrez Gene IDs
3122 (Human)
Alternate Names
FLJ51114; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLADR; HLA-DR; HLA-DRA; HLA-DRA1; major histocompatibility complex, class II, DR alpha; MHC cell surface glycoprotein; MHC class II antigen DRA; MHC Class II DR; MLRW

Product Datasheets

Citations for Human HLA-DR PerCP-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection.
    Authors: Marinho C, Azeredo E, Torrentes-Carvalho A, Marins-Dos-Santos A, Kubelka C, de Souza L, Cunha R, de-Oliveira-Pinto L
    PLoS ONE, 2014;9(7):e102014.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1.
    Authors: Schwenk, Robert, Banania, Glenna, Epstein, Judy, Kim, Yohan, Peters, Bjoern, Belmonte, Maria, Ganeshan, Harini, Huang, Jun, Reyes, Sharina, Stryhn, Anette, Ockenhouse, Christia, Buus, Soren, Richie, Thomas L, Sedegah, Martha
    Malar J, 2013;12(0):376.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Vemurafenib enhances MHC induction in BRAF homozygous melanoma cells.
    Authors: Sapkota B, Hill C, Pollack B
    Oncoimmunology, 2013;2(1):e22890.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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