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203 results for "CRBN" in 产品

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CRBN Products

Modulates cell surface expression of KCNT1 . May be involved in memory and learning

CRBN Antibody - BSA Free

Catalog #: NBP1-91810
(1)
Citations (31)
Product Documents
Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Polyclonal
Applications: KO, WB, ICC/IF, Simple Western, Mycoplasma, + 1 More
Immunocytochemistry/ Immunofluorescence: CRBN Antibody [NBP1-91810]
(8)

Recombinant Human DDB1/CRBN Complex Protein, CF

Catalog #: E3-500
Citations (1)
Product Documents
Reactivity: Human
Source: Sf 21 (baculovirus)
Accession #: Q16531.1, Q96SW2.1
Applications: Bioactivity
R&D Systems Recombinant Proteins and Enzymes

Recombinant Human CUL4A/RBX1/DDB1/CRBN Complex Protein, CF

Catalog #: E3-650
Product Documents
Reactivity: Human
Source: Sf 21 (baculovirus)
Accession #: Q13619.3 (CUL4A); P62877.1 (RBX1); Q16531.1 (DDB1), Q96SW2.1 (CRBN)
Applications: Bioactivity
R&D Systems Recombinant Proteins and Enzymes

CRBN Antibody - BSA Free

Catalog #: NBP2-82079
Product Documents
Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Polyclonal
Applications: IHC, WB, ELISA, ICC/IF
CRBN Antibody - BSA Free
(7)

CRBN Antibody - Azide and BSA Free

Catalog #: H00051185-B01P
Citations (6)
Product Documents
Reactivity: Human
Details: Mouse IgG Polyclonal
Applications: IHC, WB, IP
Western Blot: CRBN Antibody [H00051185-B01P]

Recombinant Human CRBN GST (N-Term) Protein

Catalog #: H00051185-P01
(1)
Citations (2)
Product Documents
Reactivity: Human
Source: Wheat germ
Applications: WB, ELISA, AP, MA
SDS-PAGE: Recombinant Human CRBN GST (N-Term) Protein [H00051185-P01]

Thalidomide

Catalog #: 0652
Citations (50)
Product Documents

Binds cereblon; also TNF-α synthesis inhibitor

Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide
Purity: ≥98%
Binds cereblon; also TNF-α synthesis inhibitor

dTAG-13-NEG

Catalog #: 6916
Citations (2)
Product Documents

Negative control for dTAG-13 (Cat. No. 6605)

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥97%
Negative control for dTAG-13 (Cat. No. 6605)

Human CRBN Antibody

Catalog #: MAB9574
(1)
Citations (4)
Product Documents
Reactivity: Human
Details: Mouse IgG2B Monoclonal Clone #978015
Applications: IHC, ICC/IF
CRBN antibody in RAW 264 by Immunocytochemistry (ICC).7 Mouse Cell Line by Immunocytochemistry (ICC).
(2)

Recombinant Human CUL4A/RBX1/DDB1/CRBN Complex Protein, CF

Catalog #: E3-651
Product Documents

His10 Neddylated

Reactivity: Human
Source: Sf 21 (baculovirus)
Accession #: Q13619.3 (CUL4A); P62877.1 (RBX1); Q16531.1 (DDB1), Q96SW2.1 (CRBN)
Applications: Bioactivity
R&D Systems Recombinant Proteins and Enzymes

Lenalidomide

Catalog #: 6305
(1)
Citations (8)
Product Documents

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98%
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

ZNL 02-096

Catalog #: 7240
Citations (2)
Product Documents

Potent and selective Wee1 Degrader (PROTAC®)

Chemical Name: 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: ≥98%
Potent and selective Wee1 Degrader (PROTAC®)

CRBN-6-5-5-VHL

Catalog #: 6948
Product Documents

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name: (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥96%
Application of CRBN-6-5-5-VHL in MM1S cells for CRBN-6-5-5-VHL
(2)

Pomalidomide 4'-alkylC3-acid

Catalog #: 7096
Product Documents

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name: 4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butanoic acid
Purity: ≥95%
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Pomalidomide 4'-PEG2-acid

Catalog #: 7212
Product Documents

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Chemical Name: 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic acid
Purity: ≥95%
Cereblon ligand with PEG linker and terminal acid for onward chemistry

Thalidomide-Cyanine 5

Catalog #: 7288
Citations (100)
Product Documents

High affinity cereblon fluorescent probe

Chemical Name: 2-((1E,3E)-5-((E)-1-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-5-sulfonate
Purity: ≥90%
High affinity cereblon fluorescent probe

Pomalidomide 4'-PEG1-azide

Catalog #: 7434
Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95%
Cereblon ligand with PEG linker and terminal azide for onward chemistry

Pomalidomide 4'-alkylC2-azide

Catalog #: 7439
Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95%
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Lenalidomide 5'-piperazine-4-methylpiperidine

Catalog #: 7473
Product Documents

Cereblon ligand with terminal piperidine for onward chemistry

Chemical Name: 3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride
Purity: ≥94%
Cereblon ligand with terminal piperidine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC4-azide

Catalog #: 6300
Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Alternate Names: Azido-Thalidomide
Chemical Name: N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98%
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Thalidomide-4-hydroxyacetate

Catalog #: 6466
Product Documents

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name: 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
Purity: ≥98%
Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Thalidomide 4'-oxyacetamide-PEG3-amine

Catalog #: 6467
(1)
Product Documents

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: Thalidomide - linker 1
Chemical Name: N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity: ≥95%
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-ether-alkylC6-amine

Catalog #: 6627
(1)
Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: Thalidomide - linker 4
Chemical Name: 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95%
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Pomalidomide 4'-PEG2-amine

Catalog #: 6637
(1)
Product Documents

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: Pomalidomide - linker 1
Chemical Name: 4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Purity: ≥95%
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC5-acid

Catalog #: 6682
Product Documents

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names: Pomalidomide - linker 3
Chemical Name: 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
Purity: ≥95%
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
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