21 results for "Integrin Receptor Inhibitors Small Molecules and Peptides" in 产品
Integrin Receptor Inhibitors Small Molecules and Peptides
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of α and β subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
Integrins 'integrate' the extracellular environment with the cell interior by binding both the extracellular matrix (ECM) and the cytoskeleton. They are critical for cell attachment to the ECM, which is ...
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
| Chemical Name: | 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride |
| Purity: | ≥98% |
Selective α4β1 (VLA-4) inhibitor
| Purity: | ≥95% |
Selective inhibitor of integrin α2β1
| Chemical Name: | 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide |
| Purity: | ≥98% |
Integrin binding sequence; inhibits integrin receptor function
| Purity: | ≥95% |
Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
| Chemical Name: | N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt |
| Purity: | ≥98% |
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
| Chemical Name: | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
| Purity: | ≥98% |
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
| Chemical Name: | N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine |
| Purity: | ≥98% |
Potent and selective α1β1 inhibitor
| Purity: | ≥95% |
Potent negative allosteric modulator of LFA-1
| Chemical Name: | (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione |
| Purity: | ≥98% |
Potent and selective inhibitor of integrins αvβ3 and αvβ5
| Alternate Names: | EMD121974 |
| Purity: | ≥95% |
α5β1 integrin receptor antagonist
| Purity: | ≥95% |
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
| Purity: | ≥95% |
α4β1 (VLA-4) antagonist
| Chemical Name: | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
| Purity: | ≥98% |
Potent inhibitor of the LFA-1/ICAM-1 interaction
| Chemical Name: | (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one |
| Purity: | ≥98% |
Potent inhibitor of the LFA-1/ICAM interaction
| Chemical Name: | 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid |
| Purity: | ≥98% |
Potent and selective α5β1 integrin inhibitor
| Chemical Name: | N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine |
| Purity: | ≥98% |
α2 integrin inhibitor; anti-angiogenic
| Chemical Name: | 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide |
| Purity: | ≥98% |
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
| Chemical Name: | (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid |
| Purity: | ≥98% |
Potent αv integrin inhibitor
| Chemical Name: | 3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine |
| Purity: | ≥97% |
ανβ6 integrin inhibitor
| Chemical Name: | N-[1-Oxo-5-(2-pyridinylamino)pentyl]-O-(phenylmethyl)-L-seryl-3-(3,5-dichlorophenyl)-β-alanine hydrochloride |
| Purity: | ≥98% |
Minimal recognition sequence for integrin binding; potent integrin inhibitor
| Purity: | ≥95% |
