21 results for "Integrin Receptor Inhibitors" in 产品

Integrin Receptor Inhibitors

Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of α and β subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Integrins 'integrate' the extracellular environment with the cell interior by binding both the extracellular matrix (ECM) and the cytoskeleton. They are critical for cell attachment to the ECM, which is ...

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Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic

Chemical Name: 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride
Purity: ≥98%
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
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Integrin binding sequence; inhibits integrin receptor function

Purity: ≥95%
Integrin binding sequence; inhibits integrin receptor function
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Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Chemical Name: N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Purity: ≥98%
Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
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Selective α4β1 (VLA-4) inhibitor

Purity: ≥95%
Selective α4β1 (VLA-4) inhibitor
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Potent and selective α1β1 inhibitor

Purity: ≥95%
Potent and selective α1β1 inhibitor
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Potent negative allosteric modulator of LFA-1

Chemical Name: (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
Purity: ≥98%
Potent negative allosteric modulator of LFA-1
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Highly potent and selective inhibitor of integrin α4β1 (VLA-4)

Chemical Name: (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid
Purity: ≥98%
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
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Minimal recognition sequence for integrin binding; potent integrin inhibitor

Purity: ≥95%
Minimal recognition sequence for integrin binding; potent integrin inhibitor
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Potent α2β1 inhibitor; displays antithrombotic activity in vivo

Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Purity: ≥98%
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
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Selective inhibitor of integrin α2β1

Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Purity: ≥98%
Selective inhibitor of integrin α2β1
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Potent and selective inhibitor of integrins αvβ3 and αvβ5

Alternate Names: EMD121974
Purity: ≥95%
Potent and selective inhibitor of integrins αvβ3 and αvβ5
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α5β1 integrin receptor antagonist

Purity: ≥95%
α5β1 integrin receptor antagonist
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αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor

Purity: ≥95%
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
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α4β1 (VLA-4) antagonist

Chemical Name: 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid
Purity: ≥98%
α4β1 (VLA-4) antagonist
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Potent inhibitor of the LFA-1/ICAM-1 interaction

Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
Purity: ≥98%
Potent inhibitor of the LFA-1/ICAM-1 interaction
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Potent inhibitor of the LFA-1/ICAM interaction

Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
Purity: ≥98%
Potent inhibitor of the LFA-1/ICAM interaction
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Potent and selective α5β1 integrin inhibitor

Chemical Name: N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine
Purity: ≥98%
Potent and selective α5β1 integrin inhibitor
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α2 integrin inhibitor; anti-angiogenic

Chemical Name: 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
Purity: ≥98%
α2 integrin inhibitor; anti-angiogenic
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Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable

Chemical Name: (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid
Purity: ≥98%
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
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Potent αv integrin inhibitor

Chemical Name: 3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
Purity: ≥97%
Potent αv integrin inhibitor
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ανβ6 integrin inhibitor

Chemical Name: N-[1-Oxo-5-(2-pyridinylamino)pentyl]-O-(phenylmethyl)-L-seryl-3-(3,5-dichlorophenyl)-β-alanine hydrochloride
Purity: ≥98%
ανβ6 integrin inhibitor
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