New Data: AMIGOs as T Cell Suppressors

AMIGO family proteins (AMIGO1, AMIGO2 and AMIGO3) are cell adhesion molecules that exhibit homophilic and heterophilic binding properties. Relatively little is known about the function of this protein family. They play roles in neuronal axon tract development and cell adhesion. The mRNA expression of human AMIGO2 is significantly upregulated in Th2 cells comparison with Th0 and Th1 cells1, suggesting that it may be involved in Th2 cell differentiation. AMIGO2 also acts as a receptor on T cells, modulating T-cell functions in experimental autoimmune encephalomyelitis (EAE).2

Our data show that AMIGO2 and AMIGO3 act as ligands that inhibit anti-CD3 induced IL-2 secretion on CD3+ T cells, suggesting that they may be involved in T cell suppression. Although much is yet to be learned, R&D Systems offers bioactive recombinant AMIGO proteins for expanding on these initial findings.

Recombinant Human AMIGO3 Protein
Recombinant Mouse AMIGO2 Protein
Recombinant Mouse AMIGO3 Protein

AMIGOs Suppress IL-2 Secretion by T cells. Recombinant Human AMIGO3 (Catalog # 9508-AM; Left), Recombinant Mouse AMIGO2 (Catalog # 9424-AM; middle) and Recombinant Mouse AMIGO3 (Catalog # 9425-AM; Right) all inhibit anti-CD3 antibody induced IL-2 secretion in mouse CD3+ T cells.

AMIGO Proteins Available

Proteins Species Catalog No.
AMIGO  Human 2565-AM
AMIGO2  Human 2080-AM
AMIGO2 Mouse 9424-AM
AMIGO3 Human 9508-AM
AMIGO3 Mouse 9425-AM


  1. Lund, R.J. et al. (2007) J. Immunol. 178:3648.
  2. Li, Z. et al. (2017) Brain Behav. Immunol. 62:110.