(1S,3R)-ACPD

Key Product Details

Product Description

(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC₅₀ values are 5, 15, 42 and 60 μM at mGluR₂, mGluR₅, mGluR₁ and mGluR₆ respectively).

NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.

Product Specifications for (1S,3R)-ACPD

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (1S,3R)-ACPD

The following data is based on the product molecular weight 173.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

29 28 27 26 25 24 23 22 21 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	19.25 mL	96.24 mL	192.49 mL
1.5 mM	3.85 mL	19.25 mL	38.50 mL
3 mM	1.92 mL	9.62 mL	19.25 mL
15 mM	0.38 mL	1.92 mL	3.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

• Knopfel Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 1995 PMID: 7738999
• Mistry and Challis Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 1996 PMID: 8732284
• Conti Synthesis and pharmacology of 3-hydroxy-&#916²-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 2002 PMID: 12484537

Product Documents for (1S,3R)-ACPD