Catalog Number: 0284
Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
Biological Activity
Active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).

NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 30 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Metabotropic glutamate receptors: novel targets for drug development.
    Knopfel et al.
    J.Med.Chem., 1995;38:1417
  2. Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover.
    Mistry and Challis
    Br.J.Pharmacol., 1996;117:1735
  3. Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid.
    Conti et al.
    Farmaco, 2002;57:889

The citations listed below are publications that use Tocris products. Selected citations for (1S,3R)-ACPD include:

4 Citations: Showing 1 - 4
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci 2015;35:3016
  3. Drep-2 is a novel synaptic protein important for learning and memory.
    Authors: Andlauer Et al.
    J Neurosci 2014;3
  4. Long-range axonal calcium sweep induces axon retraction.
    Authors: Yamada Et al.
    Sci Adv 2008;28:4613

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