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(1S,3R)-ACPD

Catalog #: 0284
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0284/10
0284/50
(1S,3R)-ACPD | CAS No. 111900-32-4 | Group I mGluR Agonists
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Description: Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)

Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid

Purity: ≥98%

Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).

NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.

Technical Data

M.Wt:
173.17
Formula:
C7H11NO4
Solubility:
Soluble to 30 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
111900-32-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for (1S,3R)-ACPD

The citations listed below are publications that use Tocris products. Selected citations for (1S,3R)-ACPD include:

6 Citations: Showing 1 - 6

  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  2. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  3. Drep-2 is a novel synaptic protein important for learning and memory.
    Authors: Andlauer Et al.
    J Neurosci  2014;3
  4. A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
    Authors: Pasquale and Sherman
    J Neurophysiol  2013;109:2618
  5. Tone-dependent vascular responses to astrocyte-derived signals.
    Authors: Blanco Et al.
    Am J Physiol Heart Circ Physiol  2008;294:H2855
  6. Long-range axonal calcium sweep induces axon retraction.
    Authors: Yamada Et al.
    Sci Adv  2008;28:4613

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Tocris Small Molecules

(±)-trans-ACPD

0187
7 Citations
1 Review
1 Image

VersaClone cDNA Plasmids

Human mGluR1 (AAB05337) VersaClone cDNA

RDC0983

Human mGluR2 (NP_000830) VersaClone cDNA

RDC0989

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