Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
Biological Activity(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).
NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid.
Conti et al.
Metabotropic glutamate receptors: novel targets for drug development.
Knopfel et al.
Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover.
Mistry and Challis
Citations for (1S,3R)-ACPD
The citations listed below are publications that use Tocris products. Selected citations for (1S,3R)-ACPD include:
6 Citations: Showing 1 - 6
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Authors: Tang Et al.
J Neurosci 2015;35:3016
Drep-2 is a novel synaptic protein important for learning and memory.
Authors: Andlauer Et al.
J Neurosci 2014;3
A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
Authors: Pasquale and Sherman
J Neurophysiol 2013;109:2618
Tone-dependent vascular responses to astrocyte-derived signals.
Authors: Blanco Et al.
Am J Physiol Heart Circ Physiol 2008;294:H2855
Long-range axonal calcium sweep induces axon retraction.
Authors: Yamada Et al.
Sci Adv 2008;28:4613
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
VersaClone cDNA Plasmids
Reviews for (1S,3R)-ACPD
There are currently no reviews for this product. Be the first to review (1S,3R)-ACPD and earn rewards!
Have you used (1S,3R)-ACPD?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image