A highly potent and subtype-selective agonist for the α
2 and α
2 nicotinic acetylcholine receptors. Activates α
-CTx-MII-sensitive and -insensitive components of [3
H]dopamine release from rat striatal synaptosomes, corresponding to α
2 and α
values are 12.7 and ~35 nM respectively). ~5000-, 25000- and 140000-fold selective over α
7 and muscle nAChR receptors respectively. Precursor
(Cat. No. 1527) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.
Koren et al.
Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380.
Mogg et al.
5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors.
Mukhin et al.
The citations listed below are publications that use Tocris products. Selected citations for 5-Iodo-A-85380 dihydrochloride include:
Showing Results 1 - 3 of 3