5-Iodo-A-85380 dihydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:1518
Chemical Name:3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride
Product Details
Citations (3)
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Reviews
Biological Activity
A highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors. Activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000-, 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively.

Precursor also available.

Technical Data
  • M.Wt:
    363.03
  • Formula:
    C9H11IN2O.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1217837-17-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5-Iodo-A-85380 dihydrochloride include:

3 Citations: Showing 1 - 3
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  1. Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.
    Authors: Brown and Wonnacott
    Pharmacol Res Perspect  2015;40:2047
  2. Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.
    Authors: Chatzidaki Et al.
    Neurochem Res  2015;10:e0125116
  3. Photoaffinity labeling the agonist binding domain of alpha4beta4 and alpha4beta2 neuronal nicotinic acetylcholine receptors with [(125)I]epibatidine and 5[(125)I]A-85380.
    Authors: Hamouda Et al.
    Biochim Biophys Acta  2009;1788:1987

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