Catalog Number: 3653
Alternate Names: 3a,5a-THPROG
Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Biological Activity
GABAA receptor positive allosteric modulator. Neuroactive steroid.

Deuterated analog also available.

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Neurosteroids act on recombinant human GABAA receptors.
    Puia et al.
    Neuron, 1990;4:759
  2. Neurosteroids: endogenous regulators of the GABAA receptor.
    Belelli and Lambert
    Nat.Rev.Neurosci., 2005;6:565
  3. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
    Agis-Balboa et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:14602

The citations listed below are publications that use Tocris products. Selected citations for Allopregnanolone include:

1 Citations: Showing 1 - 1

  1. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits 2013;7:144
Tocris Small Molecules
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Allopregnanolone - d5

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