Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Biological ActivityAllopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Neurosteroids act on recombinant human GABAA receptors.
Puia et al.
Neurosteroids: endogenous regulators of the GABAA receptor.
Belelli and Lambert
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Agis-Balboa et al.
Citations for Allopregnanolone
The citations listed below are publications that use Tocris products. Selected citations for Allopregnanolone include:
2 Citations: Showing 1 - 2
Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
Authors: Ferando and Mody
Front Neural Circuits 2013;7:144
Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors.
J Pharmacol Exp Ther 2011;337:301
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