Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Biological ActivityAllopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Neurosteroids act on recombinant human GABAA receptors.
Puia et al.
Neurosteroids: endogenous regulators of the GABAA receptor.
Belelli and Lambert
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Agis-Balboa et al.
Citations for Allopregnanolone
The citations listed below are publications that use Tocris products. Selected citations for Allopregnanolone include:
2 Citations: Showing 1 - 2
Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
Authors: Ferando and Mody
Front Neural Circuits 2013;7:144
Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors.
J Pharmacol Exp Ther 2011;337:301
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