AM 404 (in Tocrisolve™ 100)
Discontinued Product
Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological Activity
Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM), in water-soluble emulsion (for details see TocrisolveTM 100 Cat. No. 1684). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available as solid AM 404 (Cat. No. 1116).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Functional role of high-affinity anandamide transport, as revealed by selective inhibition.
Beltramo et al.
Science, 1997;277:1094 -
Potentiation of anandamide hypotension by the transport inhibitor, AM 404.
Calignano et al.
Eur.J.Pharmacol., 1997;337:R1 -
Structural determinants for recognition and translocation by the anandamide transporter.
Piomelli et al.
Proc.Natl.Acad.Sci.U.S.A., 1999;96:5802 -
The anandamide transport inhibitor AM404 activates vanilloid receptors.
Zygmunt et al.
Eur.J.Pharmacol., 2000;396:39
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for AM 404 (in Tocrisolve™ 100)
The citations listed below are publications that use Tocris products. Selected citations for AM 404 (in Tocrisolve™ 100) include:
2 Citations: Showing 1 - 2
-
2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells.
Authors: Costa Et al.
Reproduction 2014;147:301
-
Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex.
Authors: Tan Et al.
J Neurosci 2011;31:5300
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for AM 404 (in Tocrisolve™ 100)
There are currently no reviews for this product. Be the first to review AM 404 (in Tocrisolve™ 100) and earn rewards!
Have you used AM 404 (in Tocrisolve™ 100)?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
