Anandamide (in Tocrisolve™ 100)
Chemical Name: N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological ActivityEndogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100, Cat. No. 1684). Ki values are 89 and 371 nM for CB1 and CB2 receptors respectively; EC50 values are 18, 31 and 27 nM at GPR55, CB1 and CB2 respectively; pKi = 5.68 for rVR1. Also blocks TNF-α-induced NF-kB activation via direct inhibition of IKK.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacology of cannabinoid receptor ligands.
The orphan receptor GPR55 is a novel cannabinoid receptor.
Ryberg et al.
Characterization of the anandamide-induced depolarization of guinea-pig isolated vagus nerve.
Kagaya et al.
Complex regional haemodynamic effects of anandamide in conscious rats.
Gardiner et al.
Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway.
Sancho et al.
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens.
Ross et al.
Citations for Anandamide (in Tocrisolve™ 100)
The citations listed below are publications that use Tocris products. Selected citations for Anandamide (in Tocrisolve™ 100) include:
6 Citations: Showing 1 - 6
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors.
Authors: Diniz Et al.
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Authors: Mair Et al.
Br J Pharmacol 2010;161:176
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Authors: Ho and Gardiner
Cereb Cortex 2009;156:94
'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.
Authors: Ho Et al.
Br J Pharmacol 2008;155:837
Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
Authors: Derbenev Et al.
Cell Death Differ 2006;26:9666
Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways.
Authors: Movsesyan Et al.
Br J Pharmacol 2004;11:1121
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