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Anandamide (in Tocrisolve™ 100)

Catalog #: 1017
6 Citations Datasheet / COA / SDS

Discontinued Product

1017 has been discontinued.
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Anandamide (in Tocrisolve™ 100) | CAS No. 94421-68-8 | Non-selective Cannabinoid Receptor Agonists
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Description: Endogenous CB receptor agonist (in water-soluble emulsion)
Alternative Names: Arachidonylethanolamide,AEA

Chemical Name: N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100, Cat. No. 1684). Ki values are 89 and 371 nM for CB1 and CB2 receptors respectively; EC50 values are 18, 31 and 27 nM at GPR55, CB1 and CB2 respectively; pKi = 5.68 for rVR1. Also blocks TNF-α-induced NF-kB activation via direct inhibition of IKK.

Available as the pure oil dissolved in ethanol, Anandamine. Tocrisolve Control also available.

Technical Data

M.Wt:
347.54
Formula:
C22H37NO2
Storage:
Store at +4°C
CAS No:
94421-68-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Anandamide (in Tocrisolve™ 100)

The citations listed below are publications that use Tocris products. Selected citations for Anandamide (in Tocrisolve™ 100) include:

6 Citations: Showing 1 - 6

  1. Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors.
    Authors: Diniz Et al.
    PeerJ  2019;7:e6493
  2. Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
    Authors: Mair Et al.
    Br J Pharmacol  2010;161:176
  3. Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
    Authors: Ho and Gardiner
    Cereb Cortex  2009;156:94
  4. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.
    Authors: Ho Et al.
    Br J Pharmacol  2008;155:837
  5. Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
    Authors: Derbenev Et al.
    Cell Death Differ  2006;26:9666
  6. Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways.
    Authors: Movsesyan Et al.
    Br J Pharmacol  2004;11:1121

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