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ANAVEX 2-73

Catalog #: 5058 Datasheet / COA / SDS

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5058 has been discontinued.
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ANAVEX 2-73 | CAS No. 195615-84-0 | Sigma1 Receptor Agonists
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Description: Mixed σ1 and muscarinic receptor agonist; exhibits neuroprotective effects

Chemical Name: Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride

Purity: ≥98%

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Biological Activity

σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity.

Technical Data

M.Wt:
317.85
Formula:
C19H23NO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
195615-84-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative.
    Villard et al.
    J.Psychopharmacol., 2010;25:1101
  2. Blockade of tau hyperphosphorylation and Aβ1-42 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ1 receptor agonist, in a nontrans
    Lahmy et al.
    Neuropsychopharmacology, 2013;38:1706

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