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Anti-PAR Polyclonal Antibody (Rabbit)

Catalog #: 4336-BPC-100
26 Citations Datasheet / COA / SDS
Newer Version Available: 4335-MC-100
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Discontinued Product

4336-BPC-100 has been discontinued and is replaced by 4335-MC-100.

Product Details
Citations (26)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Anti-PAR Polyclonal Antibody (Rabbit) Summary

Source
Polyclonal Rabbit IgG
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
ELISA
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: PAR/pADPr

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Long Name
Poly [ADP-ribose] Polymer
Alternate Names
pADPr; PAR; Poly(ADP-ribose)

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Citations for Anti-PAR Polyclonal Antibody (Rabbit)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

26 Citations: Showing 1 - 10
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  1. p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis
    Authors: Elfar, GA;Aning, O;Ngai, TW;Yeo, P;Chan, JWK;Sim, SH;Goh, L;Yuan, J;Phua, CZJ;Yeo, JZZ;Mak, SY;Goh, BKP;Chow, PK;Tam, WL;Ho, YS;Cheok, CF;
    Nucleic acids research
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development
    Authors: Kamaletdinova, T;Zong, W;Urbánek, P;Wang, S;Sannai, M;Grigaravi?ius, P;Sun, W;Fanaei-Kahrani, Z;Mangerich, A;Hottiger, MO;Li, T;Wang, ZQ;
    Cells
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  3. Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
    Authors: Fontana, P;Buch-Larsen, SC;Suyari, O;Smith, R;Suskiewicz, MJ;Schützenhofer, K;Ariza, A;Rack, JGM;Nielsen, ML;Ahel, I;
    Nature communications
    Species: Drosophila melanogaster
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. PARP1 Regulates Circular RNA Biogenesis though Control of Transcriptional Dynamics
    Authors: Eleazer, R;De Silva, K;Andreeva, K;Jenkins, Z;Osmani, N;Rouchka, EC;Fondufe-Mittendorf, Y;
    Cells
    Species: Drosophila
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage
    Authors: AS Singatulin, MV Sukhanova, B Desforges, V Joshi, D Pastré, OI Lavrik
    Cells, 2022-12-05;11(23):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. PARP1's Involvement in RNA Polymerase II Elongation: Pausing and Releasing Regulation through the Integrator and Super Elongation Complex
    Authors: EA Matveeva, H Dhahri, Y Fondufe-Mi
    Cells, 2022-10-12;11(20):.
    Species: Drosophila
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Effects of the PARP Inhibitor Olaparib on the Response of Human Peripheral Blood Leukocytes to Bacterial Challenge or Oxidative Stress
    Authors: SS Santos, MKC Brunialti, LOCP Rodrigues, AMA Liberatore, IHJ Koh, V Martins, FG Soriano, C Szabo, R Salomão
    Biomolecules, 2022-06-04;12(6):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  8. Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer
    Authors: M Stanzione, J Zhong, E Wong, TJ LaSalle, JF Wise, A Simoneau, DT Myers, S Phat, M Sade-Feldm, MS Lawrence, MK Hadden, L Zou, AF Farago, NJ Dyson, BJ Drapkin
    Science Advances, 2022-05-13;8(19):eabn1229.
    Species: Xenograft
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  9. Olaparib Induced Senescence is Bypassed through G2/M Checkpoint Override in Olaparib Resistant Prostate Cancer
    Authors: AP Lombard, CM Armstrong, LS D'Abronzo, S Ning, AR Leslie, M Sharifi, W Lou, CP Evans, M Dall'Era, HW Chen, X Chen, AC Gao
    Molecular Cancer Therapeutics, 2022-04-01;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  10. A Novel CDK4/6 and PARP Dual Inhibitor ZC-22 Effectively Suppresses Tumor Growth and Improves the Response to Cisplatin Treatment in Breast and Ovarian Cancer
    Authors: C Tian, Y Wei, J Li, Z Huang, Q Wang, Y Lin, X Lv, Y Chen, Y Fan, P Sun, R Xiang, A Chang, S Yang
    International Journal of Molecular Sciences, 2022-03-07;23(5):.
  11. Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic
    Authors: KL Cooper, LB Volk, DR Dominguez, AD Duran, KJ Ke Jian Li, LG Hudson
    Toxicology and Applied Pharmacology, 2021-11-16;434(0):115799.
    Species: Human
    Sample Types: Protein
    Applications: ELISA Detection
  12. ATR regulates neuronal activity by modulating presynaptic firing
    Authors: M Kirtay, J Sell, C Marx, H Haselmann, M Ceanga, ZW Zhou, V Rahmati, J Kirkpatric, K Buder, P Grigaravic, A Ori, C Geis, ZQ Wang
    Nature Communications, 2021-07-01;12(1):4067.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  13. New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy
    Authors: Z Zhou, F Huang, I Shrivastav, R Zhu, A Luo, M Hottiger, I Bahar, Z Liu, M Cristofani, Y Wan
    EMBO Mol Med, 2020-11-24;12(12):e12391.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  14. Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
    Authors: HD Chen, N Guo, SS Song, CH Chen, ZH Miao, JX He
    Am J Cancer Res, 2020-09-01;10(9):2813-2831.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
    Authors: EF Fang, Y Hou, S Lautrup, MB Jensen, B Yang, T SenGupta, D Caponio, R Khezri, TG Demarest, Y Aman, D Figueroa, M Morevati, HJ Lee, H Kato, H Kassahun, JH Lee, D Filippelli, MN Okur, A Mangerich, DL Croteau, Y Maezawa, CA Lyssiotis, J Tao, K Yokote, TE Rusten, MP Mattson, H Jasper, H Nilsen, VA Bohr
    Nat Commun, 2019-11-21;10(1):5284.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  16. AsiDNA Treatment Induces Cumulative Antitumor Efficacy with a Low Probability of Acquired Resistance
    Authors: W Jdey, M Kozlak, S Alekseev, S Thierry, P Lascaux, PM Girard, F Bono, M Dutreix
    Neoplasia, 2019-07-27;21(9):863-871.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ELISA Detection
  17. PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA
    Authors: AS Singatulin, L Hamon, MV Sukhanova, B Desforges, V Joshi, A Bouhss, OI Lavrik, D Pastré
    Cell Rep, 2019-05-07;27(6):1809-1821.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  18. Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets
    Authors: S Lodovichi, A Mercatanti, T Cervelli, A Galli
    Oncotarget, 2019-04-12;10(28):2722-2737.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  19. Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours
    Authors: LD Ordonez, T Hay, R McEwen, UM Polanska, A Hughes, O Delpuech, E Cadogan, S Powell, J Dry, G Tornillo, L Silcock, E Leo, MJ O'Connor, AR Clarke, MJ Smalley
    Oncotarget, 2019-04-05;10(27):2586-2606.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  20. PARP1 is a versatile factor in the regulation of mRNA stability and decay
    Authors: EA Matveeva, LF Mathbout, YN Fondufe-Mi
    Sci Rep, 2019-03-06;9(1):3722.
    Species: Drosophila melanogaster
    Sample Types: Cell Lysates
    Applications: Western Blot
  21. PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation
    Authors: G Ngo, S Hyatt, J Grimstead, R Jones, E Hendrickso, C Pepper, D Baird
    Oncotarget, 2018-12-25;9(101):37549-37563.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  22. Naringenin has a chemoprotective effect in MDA-MB-231 breast cancer cells via inhibition of caspase-3 and -9 activities
    Authors: R Wang, J Wang, T Dong, J Shen, X Gao, J Zhou
    Oncol Lett, 2018-11-15;17(1):1217-1222.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  23. Hydrogen?rich medium alleviates high glucose?induced oxidative stress and parthanatos in rat Schwann cells in�vitro
    Authors: Q Li, Y Jiao, Y Yu, G Wang, Y Yu
    Mol Med Rep, 2018-11-08;0(0):.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  24. Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib.
    Authors: Murai J, Huang S, Renaud A, Zhang Y, Ji J, Takeda S, Morris J, Teicher B, Doroshow J, Pommier Y
    Mol Cancer Ther, 2013-12-19;13(2):433-43.
    Species: Chicken
    Sample Types: Cell Lysates
    Applications: Western Blot
  25. PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.
    Authors: Cheng H, Zhang Z, Borczuk A, Powell C, Balajee A, Lieberman H, Halmos B
    Carcinogenesis, 2012-12-28;34(4):739-49.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  26. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.
    Authors: Murai J, Huang S, Das B, Renaud A, Zhang Y, Doroshow J, Ji J, Takeda S, Pommier Y
    Cancer Res, 2012-11-01;72(21):5588-99.
    Species: Chicken, Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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