Axin-2 Antibody

Novus Biologicals | Catalog # NBP3-12289

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit
View all Axin-2 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for Axin-2 Antibody

Western Blot: Axin-2 Antibody [NBP3-12289]

Western Blot: Axin-2 Antibody [NBP3-12289]

Western Blot: Axin-2 Antibody [NBP3-12289] - Rat cerebral cortex (A) and spinal cord (B) samples. 1:500 diluted in DiluoBuffer. Apparent MW is 63 KDa.
Immunohistochemistry-Paraffin: Axin-2 Antibody [NBP3-12289]

Immunohistochemistry-Paraffin: Axin-2 Antibody [NBP3-12289]

Immunohistochemistry-Paraffin: Axin-2 Antibody [NBP3-12289] - Mouse Lung. 1:50 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.
Immunohistochemistry-Paraffin: Axin-2 Antibody [NBP3-12289]

Immunohistochemistry-Paraffin: Axin-2 Antibody [NBP3-12289]

Immunohistochemistry-Paraffin: Axin-2 Antibody [NBP3-12289] - Mouse Lung. 1:50 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.

Applications for Axin-2 Antibody

Application
Recommended Usage

ELISA

1:10000

Immunohistochemistry

1:50-1:100

Immunohistochemistry-Paraffin

1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.

Background: Axin-2

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. (provided by RefSeq)

Long Name

Axis Inhibitor 2

Alternate Names

AXIL, Axin2, Conductin, MGC10366, MGC126582

Gene Symbol

AXIN2

Additional Axin-2 Products

Product Documents for Axin-2 Antibody

Certificate of Analysis

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Product Specific Notices for Axin-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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